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Drug Targets In-Depth Focus 2016

17 March 2016 | By Drug Target Review

In this Drug Targets In-Depth Focus: "The alarming increase in antibioticresistant bacteria", plus "Computational methods for drug repositioning"; and "An overview of Alzheimer’s disease drug targets"...

Interview with Amrik Basran, Chief Scientific Officer at Avacta Life Sciences

17 March 2016 | By Caroline Richards (Drug Target Review)

Caroline Richards, Editor of Drug Target Review, asks Amrik Basran, Chief Scientific Officer at Avacta Life Sciences, to provide his views on Affimer® technology...

Microfluidics: The fur-free way towards personalised medicine in cancer therapy

17 March 2016 | By Amy Dawson (University of Hull), John Greenman (University of Hull), Ruth Bower (University of Hull), Victoria Green (University of Hull)

Microfluidic technology has great potential for complementing and, in some instances, replacing the use of animal models in the testing of medicines and in developing personalised treatments for cancer patients.

Pushing the limits of protein expression with miRNAs

17 March 2016 | By Kerstin Otte Biberach (University of Applied Sciences), René Handrick (University of Applied Sciences), Simon Fischer (Boehringer Ingelheim)

Biopharmaceuticals are highly complex protein drugs such as antibodies, cytokines and peptide hormones, which are used for a variety of indication areas, including immunology, neurology, metabolic diseases and cancer. These modern protein drugs may hinder progression of a disease, ease symptoms or assure – in the case of chronic diseases…

Strategies for identifying predictive biomarkers of non-alcoholic fatty liver disease

17 March 2016 | By James Adjaye (Heinrich-Heine-University), Marie-Ann Kawala (Heinrich-Heine-University), Nina Graffmann (Heinrich-Heine-University), Wasco Wruck (Heinrich-Heine-University)

Non-alcoholic fatty liver disease (NAFLD), a consequence of sedentary life styles and high fat diets, has an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms within genes such as PNPLA3, TM6SF2, APOC3, NCAN and PPP1R3B correlate…

Classifying brain tumours to improve diagnoses

17 March 2016 | By Xiaolong Fan (Beijing Normal University)

Brain tumours are complex cancer types, arising in many unique forms, each having varying survival rates and differing methods of treatment. Many brain tumours are difficult to clearly diagnose, leading to poor patient prognoses. Although they are mainly diagnosed by analysing morphological appearance, this does not closely correlate with the…

UK life sciences are stronger in the EU, says BioIndustry Association

16 March 2016 | By Steve Bates, BioIndustry Association (BIA) Chief Executive

Here, Steve Bates, Chief Executive of the BioIndustry Association (BIA), makes a case for the UK remaining in the EU from the perspective of the life sciences sector...

Browsing for drug targets

8 March 2016 | By Edward D. Zanders, PharmaGuide Ltd, Cambridge, UK

Here, Edward D. Zanders explains his motivation behind writing ‘Human Drug Targets a Compendium for Pharmaceutical Discovery’ - a collection of current and potential drug targets mapped to human genes curated by the HGNC...

The case for data analytics in proof of concept studies

26 February 2016 | By Rodrigo Barnes, Chief Technology Officer at Aridhia

Here, Rodrigo Barnes, Chief Technology Officer at Aridhia, discusses how data analytics can add value to proof of concept trials...

Directing a weaponised attack on cancer with Natural Killer Receptor T-Cells

23 February 2016 | By Dr Frédéric Lehmann, VP Immuno-Oncology, Celyad

Natural killer receptor T-cells have the potential to become a real game changing treatment for patients with cancer. Here, Dr Frédéric Lehmann, VP Immuno-Oncology, Celyad, discusses this new cancer fighting technology...

An overview of Alzheimer’s disease drug targets

17 February 2016 | By Maria Kuzikov (Fraunhofer-IME SP), Sheraz Gul (Fraunhofer-IME SP)

Alzheimer’s disease (AD) is the most common form of dementia which typically occurs after the age of 65 and is characterised by progressive cognitive impairment...

Computational methods for drug repositioning

17 February 2016 | By Anaum Rashid (University of Sunderland), Hannah Smith (University of Sunderland), Ken McGarry (University of Sunderland)

Bioinformatics and computational techniques are now experiencing increased attention as a means of improving the costly and time-consuming drug development process...

The frightening emergence of antibiotic-resistant bacteria

17 February 2016 | By Jean-Marie Frere (CIP Universite de Liege), Sebastien Rigali (CIP Universite de Liege)

Bacterial resistance to antibiotics is on the rise and a return to the ‘pre-antibiotic’ era has become a frightening possibility. Various factors are responsible for this situation: the overuse of antibiotics in human medicine and animal husbandry, insufficient public funding for research into fundamental bacteriology including resistance mechanisms, and a…

The relevance of homogeneous radiometric assays in modern drug discovery

14 February 2016 | By Gabriele Sorg (Hit Discovery Constance), Horst Flotow (Singapore Screening Centre)

In the past two decades, several alternative, non-radiometric assay formats have been developed for the high-throughput screening (HTS) of target classes such as protein kinases, which were previously screened using radiometric assays. Radiometric screening (and the expertise to perform such HTS) has thus declined in recent years...

Finding a cure for neglected tropical diseases with cell-based assays

14 February 2016 | By David Shum (Institut Pasteur Korea)

Neglected tropical diseases pose a significant threat to public health and affect nearly one billion people in tropical and sub-tropical regions throughout the world. There is a pressing need to identify new therapeutics for NTDs and many developed nations are participating in drug discovery efforts...

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