Drug Discovery News, Articles, Events

Peptides: a promising alternative to opioids for chronic pain relief

In an exclusive with Drug Target Review, researchers at the University at Buffalo explain how they developed a novel peptide that could be a future treatment for chronic inflammatory pain.

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Cardiac proarrhythmic risk assessment using human-induced pluripotent stem cell-derived cardiomyocytes

Watch this on-demand webinar to learn how the two assays developed by Eurofins provide a more comprehensive pre-clinical model for cardiac liability assessment.

Editor's Spotlight

Brochure: Biologics workflow solutions brochure

By PerkinElmer

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UTX gene mutation “robs” individuals of natural cancer protection

By Anna Begley (Drug Target Review)

Novel intestine chip enables effective in vitro study of COVID-19 therapies

By Anna Begley (Drug Target Review)

Human iPSC-derived cardiomyocytes for cardiac proarrhythmic risk assessment

By Anton Simeonov, Drug Target Review, Victoria Rees (Drug Target…

Latest Drug Discovery News

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UTX gene mutation “robs” individuals of natural cancer protection

The UTX gene mutation was found to lead to an increased cancer risk, presenting a potential drug target for preventative therapies.

Elderly woman putting last piece of brain shaped puzzle

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Scientists explore CA2 neuron mitochondria for memory loss targets

The team will receive $2 million over five years to investigate the CA2 brain region for the development of neurological therapies.

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Novel intestine chip enables effective in vitro study of COVID-19 therapies

The intestine chip was infected with a coronavirus to test a variety of drugs, presenting a new method to investigate COVID-19 treatments.

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Researchers achieve DNA methylation removal in mouse models

The study showed that DNA “de-methylation” activity can be targeted to anywhere in the DNA and may be a new therapeutic strategy.

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MicroRNA in red blood cells causes vascular damage in type 2 diabetes

Researchers discovered that cardiovascular damage was caused by reduced microRNA-210 levels in patient cells and mice with type 2 diabetes.

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Soluble fibrinogen a potential target for neurodegeneration

In a pre-clinical study, fibrinogen increased the death of mouse brain neurons, suggeting fibrin can have similar toxic effects on neurons.

Beyond The Lab Reports

ebook: High-Throughput Data Management in process development

Cell Line Development and cell culture process teams, are you geared up to leverage the vast amount of data generated by high-throughput?

ebook: Optimise your high value cell lines

As interest in biotherapeutic proteins grows, the need to reduce cell line development costs and the time to market is more critical than ever.

ebook: Why you need to digitally transform your R&D organisation

Despite many companies considering digital transformation a top priority, research shows that 70% of digital transformation initiatives fail. In this ebook, we explore why and how the right approach can see your organisation succeed.

ebook: How automation makes labs more efficient

We discuss how liquid handling automation supports drug discovery workflows & highlight opportunities to improve the efficiency and quality of these.

Articles from Drug Target Review

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Human iPSC-derived cardiomyocytes for cardiac proarrhythmic risk assessment

Following Drug Target Review's webinar supported by Eurofins, speaker Dr Verena Albert answers the questions posed by the audience during…

By Anton Simeonov, Drug Target Review, Victoria Rees (Drug Target…

article

Are computer simulations the future of rapid COVID-19 drug development?

Researchers have visualised SARS-CoV-2 protein dynamics using in silico methods. In this article, Navodya Roemer explains how a team from…

By Navodya Roemer (University of Lincoln)

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AI & Informatics: Drug discovery and development – industry survey…

View Drug Target Review's new infographic on the use of AI and informatics within early therapeutic development here.

By Drug Target Review

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Targeting SARS-CoV-2 replication with inhibitors of lipid metabolism

One approach towards efficient drug targeting efforts for COVID-19 is to repurpose medicines developed for other diseases. Here, Professor Christopher…

By Professor Christopher Basler (Georgia State University)

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Improving drug discovery with advanced targeted proteomic monitoring workflows

In this article, Professor Forest White, Department of Biological Engineering at MIT, and Dr Lauren Stopfer, Scientist at BioNTech, present…

By Dr Lauren Stopfer (BioNTech), Professor Forest White (MIT)

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Video: PHERAstar FSX Customer testimonial

In this video, Becky Allsopp from Sygnature Discovery talks about Drug Discovery Research and how she uses the Microplate Reader…

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