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Breath test could help detect stomach and oesophageal cancers
A test that measures the levels of five chemicals in the breath has shown promising results for the detection of oesophageal and stomach cancers, in a large patient trial.
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Mass Spectrometry
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The next revolution in stratified medicine: molecular phenotyping with metabolomics
The study of biochemistry provides molecular insights into how the human population ages, how diseases commence and progress, how molecular changes relate to disease remission and relapse, and how humans respond to treatments...
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Advanced techniques and applications of LC-MS in small molecule drug discovery
A key process in drug discovery is the ability to identify new drug candidates by screening chemical libraries of small molecules, natural products or extracts against a biological target and selecting lead compounds with desirable therapeutic effects. Medicinal chemistry has the challenging role of not only ensuring that the chemical…
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Proteogenomic breast cancer study provides insight into potential therapeutic targets
26 May 2016 | By Victoria White, Digital Content Producer
Scientists have completed the first large-scale proteogenomic study of breast cancer, linking DNA mutations to protein signalling...
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Demands in medical automation technology brings two prominent players close
22 April 2016 | By Snehal Chougule, Allied Market Research
Here, Snehal Chougule discusses Trajan's recent investment in automation solution company, LEAP Technologies Inc...
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Researchers identify PHGDH inhibitor to target serine biosynthesis in cancer
8 March 2016 | By Victoria White
Researchers have shown that CBR-5884 was able to inhibit cell proliferation of breast cancer and melanoma cells lines that overexpress PHGDH...
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Analysing recombinant proteins by mass spectrometry
The drug discovery landscape is changing: no longer limited to big pharma, it is now within reach of academics and small consortia alike. Regardless of the setting, drug discovery requirements are always the same: strong biological theory, good chemical starting material and high quality protein samples from which to determine…
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Mass spectrometry and systems biology approaches in drug target discovery
Cells, organs and organisms are complex biological systems consisting of inter-related components that co-operatively work to maintain function and respond to change. Malfunction of any component can lead to pathologies and disease, leading to system-wide changes and subsequent adaptation. Hence, the ability to study and predict system behaviour will considerably…
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Drug Target Review – Issue #4 2015
3 December 2015 | By Drug Target Review
Included in this issue: Biomarkers, Mass Spectrometry, Target Validation, Drug Development, Personalised Medicines, Next-Generation Sequencing, Protein Expression, Companion Diagnostics, and much more...
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Mass Spectrometry In-Depth Focus 2015
In this Mass Spectrometry In-Depth Focus: Michelle M. Hill from University of Queensland discusses Mass spectrometric and systems biology approaches in drug target discovery, and Nicola Burgess-Brown, Rod Chalk, Claire Strain-Damerell and Pravin Mahajan from the Structural Genomics Consortium look at analysing recombinant proteins by mass spectrometry...
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Should LC-MS/MS proteomics guide targeted drug selection for cancer patients?
History has demonstrated that the use of companion in vitro diagnostic tests to select cancer patients positive for a drug target significantly improves response to targeted anti-cancer therapies...
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Proteomics In-Depth Focus 2015
In this Proteomics In-Depth Focus: David J. Britton & Pedro R. Cutillas from Barts Cancer Institute ask should LC-MS/MS proteomics guide targeted drug selection for cancer patients? And Manfred Raida from the National University of Singapore explains how mass spectrometry and drug development come together...
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Researchers identify possible ovarian cancer biomarkers
17 September 2015 | By Victoria White
The researchers also determined that the level of biomarkers associated with ovarian cancer does not simply increase or decrease over the course of the disease...
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Researchers develop a new computational method to study cancer drug effects
11 September 2015 | By Victoria White
Researchers have developed a new method for studying the targets and effects of cancer drugs using data from discovery mass spectrometry experiments...
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Lab-on-a-Chip, Microfluidics, Point-of-Care Diagnostics and Global Health, The Road to Diagnostics Congress
8 June 2015 | By Select Biosciences
Select Biosciences is delighted to announce that its flagship congress now in its 7th year in San Diego, California, USA is being held September 28-30, 2015...
