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Exosomes identified as the missing link to insulin resistance
Researchers have identified exosomes as the missing link in diabetes...
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miRNAs
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Gene-regulatory factors improve pancreatic cancer treatment
Researchers have identified two molecules that can improve the response of pancreatic cancer to a common chemotherapy drug and also predict the prognosis of pancreatic cancer patients...
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Micro-gene protects the brain from developing epilepsy
A tiny microRNA has been shown to play a beneficial role in protecting the brain from epileptic seizures in specially engineered transgenic mice.
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Valid biomarker signatures from liquid biopsies – how to standardise NGS
The advent of next-generation sequencing (NGS) techniques has revolutionised transcriptomics research and opened numerous avenues for scientific and clinical applications. While reverse transcriptase quantitative real-time polymerase chain reaction (RT-qPCR) is still considered the gold standard of gene expression analysis, its high throughput, single-nucleotide resolution and ever-plummeting costs have made NGS…
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ReNeuron pursues glioblastoma multiforme as target for exosome platform
9 June 2016 | By Victoria White, Digital Content Producer
ReNeuron selected glioblastoma multiforme based on evidence of tumour-inhibiting activity from early preclinical studies with the exosome technology...
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Restoring chemotherapy sensitivity in resistant pancreatic cancer
27 May 2016 | By Victoria White, Digital Content Producer
By increasing the level of miR-374b, researchers have restored chemotherapy sensitivity to pancreatic cancer cells that had developed resistance...
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Targaprimir-96 successfully targets breast cancer RNA
10 May 2016 | By Victoria White, Digital Content Producer
Scientists have designed a drug candidate, Targaprimir-96, that decreases the growth of tumour cells in animal models of triple negative breast cancer...
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miR551b identified as a promising target for ovarian cancer
6 May 2016 | By Victoria White, Digital Content Producer
The microRNA miR551b has been shown to impact STAT3 protein levels, contributing to resistance to cell death and increased proliferation of cancer cells...
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miR-155 deletion prevents diet-induced obesity in mice
23 March 2016 | By Victoria White
In a study, despite eating a high-fat diet for 3 months, miR-155 knockout mice did not become obese and had enhanced metabolic rates...
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Pushing the limits of protein expression with miRNAs
Biopharmaceuticals are highly complex protein drugs such as antibodies, cytokines and peptide hormones, which are used for a variety of indication areas, including immunology, neurology, metabolic diseases and cancer. These modern protein drugs may hinder progression of a disease, ease symptoms or assure – in the case of chronic diseases…
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Nanoparticles inhibit liver cancer tumour growth in study
26 January 2016 | By Victoria White
Scientists from UTSW have crafted synthetic "dendrimer" nanoparticles that are able to provide a tumour-suppressing effect without further damaging the liver or neighbouring tissue...
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Preclinical data for ReNeuron’s exosome nanomedicine platform published
12 January 2016 | By Victoria White
ReNeuron is researching the therapeutic potential of exosomes derived from its proprietary stem cell lines. The Company is also exploring the potential of its exosomes as a delivery system for gene therapy treatments...
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InteRNA Technologies secures final extension Series A financing
30 October 2015 | By Victoria White
InteRNA says the proceeds of this financing will be used to progress several of its lead product candidates...
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International consortium CANCER-ID to develop novel biomarker technologies in cancer
23 April 2015 | By Victoria White
Bayer and UKE are the main coordinators of a new international consortium, CANCER-ID, to develop novel blood-based biomarker technologies in cancer...