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Drug targets

surface of several coronavirus particles

news

COVID-19 viral envelope simulation under development

25 March 2020 | By Hannah Balfour (Drug Target Review)

Researchers are working to build a complete, all-atom model of the exterior of the coronavirus to aid in drug design.

news

Map of COVID-19 and human protein interactions reveals drug targets

24 March 2020 | By Victoria Rees (Drug Target Review)

Researchers have identified which SARS-CoV-2 proteins physically associate with proteins in human cells, revealing potential drug targets to treat the COVID-19 coronavirus.

coronavirus particles in blue with pink spike proteins on their surface

news

Chronic use of heart disease medications may increase the risk of severe COVID-19

24 March 2020 | By Hannah Balfour (Drug Target Review)

A researcher has revealed that angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs) may increase the risk of severe lung complications in COVID-19.

news

Researchers to screen compound library for antiviral drugs to combat COVID-19

23 March 2020 | By Victoria Rees (Drug Target Review)

Scripps Research has announced it will screen over 14,000 compounds to see if any present significant activity against COVID-19, for use in a therapeutic.

Coronavirus particles in green with purple extracellular proteins

news

Preliminary SARS-CoV-2 protease inhibitor shows efficacy in mice

20 March 2020 | By Victoria Rees (Drug Target Review)

Using X-ray crystallography, researchers have revealed the structure of the SARS-CoV-2 main protease, designing an inhibitor to bind to this target and prevent viral replication.

coronavirus particles in grwy with spike surface proteins in pink on a red to black gradient background

news

Mapping the immune response to COVID-19

17 March 2020 | By Hannah Balfour (Drug Target Review)

Researchers reveal that a broad range of immune cells react to COVID-19 and aid recovery, findings which could inform the development of a potential vaccine.

coronavirus with cell surface protein projections

news

Scientists demonstrate how COVID-19 infects human cells

5 March 2020 | By Hannah Balfour (Drug Target Review)

Researchers have used cryogenic electron microscopy to show that coronaviruses enter human cells through an interaction with angiotensin-converting enzyme 2 (ACE2).

news

Researchers map vital atomic-scale protein on COVID-19

20 February 2020 | By Victoria Rees (Drug Target Review)

Using cryogenic electron microscopy, a team has mapped the Spike protein on COVID-19, which could be used in the development of vaccines.

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Drug targets