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Issue #3 2020

Cocaine and the brain: identifying targets for addiction therapies

16 September 2020 | By Hannah Balfour (Drug Target Review)

There are currently no licenced pharmaceuticals to treat cocaine addiction. To overcome this issue, US researchers at the University of Alabama at Birmingham have been exploring how cocaine alters transcription in the nucleus accumbens, a region of the brain implicated in compulsive drug use. Here, Hannah Balfour discusses with Dr…

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COVID-19 therapies in the pipeline

15 September 2020 | By Sheraz Gul (Fraunhofer Institute)

As the global COVID-19 situation is rapidly changing, staying abreast with the latest news can be challenging. In this article, Sheraz Gul provides an overview of the broad range of potential treatments in development and discusses how the regulatory landscape can shift at any time.

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Understanding the limits of synthetic biology through the origins of SARS-CoV-2

15 September 2020 | By Marc Baiget Francesch (International Journal of Molecular Sciences)

Conspiracy theories about COVID-19 have been spreading since the early days of the outbreak. But how do we know whether a biological entity is artificially made or has occurred naturally? Marc Baiget Francesch explores the capabilities of current scientific approaches in terms of virus engineering and how this applies to…

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Exploring the intra-protein non-covalent interactions in the S1 domain of the SARS-CoV-2 S1 Spike protein

11 September 2020 | By Oscar Bastidas PhD (University of Minnesota)

The Spike (S) protein is a promising drug target in the quest to develop vaccines and antivirals for SARS-CoV-2 to treat and prevent COVID-19. Intra-protein interaction energy landscape mapping efforts have recently identified key interactions that may be crucial for the S protein’s ability to bind to receptor proteins on…

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Adding to the arsenal: targeting human proteins for controlling M. tuberculosis growth

11 September 2020 | By Navodita Jain (Syngene International)

The National Institute of Health envisions a plan for managing tuberculosis in the 21st century. Included in this proposal is targeting host proteins as an add-on therapy to antibiotics. Infectious disease biologists are focusing on this strategy and it is a topic of active research. Recently, a multinational research team…

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Exploring new drug targets in Alzheimer’s disease

11 September 2020 | By Monika Schmidt (University of Hradec Kralove), Sheraz Gul (Fraunhofer Institute)

Although many potential targets have been identified for Alzheimer’s disease (AD), there is no effective treatment for this debilitating condition. In this article, Monika Schmidt and Sheraz Gul delve into the key proteins implicated in AD and suggest how phenotypic assays could aid in AD drug discovery.

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Novel biomarker technology for cancer diagnostics

11 September 2020 | By Nikki Withers (Drug Target Review)

A new way of identifying cancer biomarkers has been developed by researchers at Lund University in Sweden. The new technology allows very sensitive, quick and cost-effective identification of cancer biomarkers. Nikki Withers spoke to Professor Carl Borrebaeck, who discusses how the researchers demonstrated the power of combining proteomics with genomics.

computer graphic of a DNA strand - idea of next-generation sequencing

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NGS: offering a glimmer of hope in the fight against COVID-19

11 September 2020 | By Pushpanathan Muthuirulan (Harvard University)

Next-generation sequencing (NGS) has become the method of choice for many researchers responding to infectious disease outbreaks and in the present coronavirus pandemic. Here, Pushpanathan Muthuirulan discusses the potential of NGS for rapid diagnosis and explores some of the emerging high-throughput approaches using NGS as a readout for the detection…

chromosome on an abstract blue to red gradient background - idea of next-generation sequencing of genomics

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Powering forward – Genomics England’s COVID-19 response

11 September 2020 | By Nikki Withers (Drug Target Review)

Genomics England has launched a next-generation genomic research platform that will play a key role in the response to COVID-19. It is hoped this research environment will transform how genomic data is made usable for global biopharma and academic scientists, providing world‑class patient data security, while enabling the flexibility required…

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Under the microscope: Transforming drug discovery on membrane proteins

11 September 2020 | By Creoptix

IN NOVEMBER 2017, leadXpro chose to strengthen its capabilities with the Creoptix™ WAVEsystem. “We were looking for a label‑free, biophysical method to investigate binding affinity and kinetics of small molecules with challenging integral membrane proteins,” explained Michael Hennig, Chief Executive Officer of leadXpro.

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Under the microscope: Supporting the COVID-19 response with NGS

11 September 2020 | By Takara

Responding efficiently to urgent situations is of utmost importance in times of crisis. Dr Suvarna Gandlur, Associate Director of Takara Bio’s next-generation sequencing (NGS) portfolio, discusses how the company is contributing to the COVID-19 effort and supporting the scientific community.

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Expert view: Measuring protein interactions in blood – not as trivial as it sounds

11 September 2020 | By Fluidic Analytics

In the continuing battle against COVID-19, researchers now must identify the best candidates for vaccines and convalescent serum therapies against the virus.

Evaluation of the analytical performance of the AQUIOS CL flow cytometer in a multi‑centre study

whitepaper

Whitepaper: Evaluation of the analytical performance of the AQUIOS CL flow cytometer in a multi‑centre study

11 September 2020 | By Beckman Coulter Inc

This whitepaper from Beckman Coulter evaluates the analytical performance of the AQUIOS CL flow cytometer in a multi‑centre study.

whitepaper

Application note: 3D cell panel screens for drug discovery and development

11 September 2020 | By Horizon Discovery

Horizon Discovery have developed their 3D OncoSignature™ spheroid screening service that consists of a panel of 200 cell lines. In this application note they demonstrate the ability of parallel 2D and 3D OncoSignature primary screens to identify known compounds with enhanced activity under 3D conditions.

Accurate affinity profiling of a SARS-CoV-2 antibody in serum

whitepaper

Application note: Accurate affinity profiling of a SARS-CoV-2 antibody in serum

11 September 2020 | By Fluidic Analytics

In this application note, Fluidic Analytics show that by using MDS on the Fluidity One-W Serum we can accurately detect and characterise the binding affinity of antibodies to virus proteins directly in human serum.

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Issue #3 2020