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digital issue #1 2017 in-depth focus antibodies

Antibodies In-Depth Focus 2017

15 March 2017 | By Drug Target Review

Lone Friis and David Matthews discuss developability assessment of therapeutic antibodies, and Negin Mokhtari and colleagues explain nanoparticle-mediated enzyme delivery for application in cancer therapy...

Turning rare diseases into efficient targets with AI

14 March 2017 | By Dr Patrick Keohane (Chief Medical Officer: BenevolentBio)

BenevolentBio's CMO, Dr Patrick Keohane, says the industry is on the cusp of an artificial intelligence (AI) revolution...

Q&A: Lou Matis on bispecific antibodies

9 March 2017 | By Steve Bremer (Drug Target Review)

Drug Target Review Editor Steve Bremer talks to Pieris’ Chief Development Officer Lou Matis about bispecific antibodies.

Targeting GAS6 in cancer, fibrosis and viral infection

9 March 2017 | By Amato J Giaccia (Stanford University), Raymond Tabibiazar (Aravive Biologics Inc), Rebecca Miao (Stanford University)

The growth-arrest specific 6 (GAS6) protein has emerged in recent years as an attractive target for drug development primarily because it is the sole ligand for the AXL receptor tyrosine kinase, which plays critical roles in cancer, fibrosis, and viral infection.

Nanoparticle-mediated enzyme delivery for application in cancer therapy

9 March 2017 | By Mukanth Vaidyanathan (University of California), Negin Mokhtari (University of California), Sadik Esener (University of California), Ya-San Yeh (University of California)

Enzyme therapy is a promising form of cancer treatment. The specific nature of enzyme and substrate interaction gives enzyme therapy an edge compared to standard non-specific therapies such as radiation and chemotherapy. However, since most of these enzymes are of a foreign nature, the delivery of these immunogenic enzymes has…

Drug Target Review magazine Issue #1 2017 spread

Drug Target Review – Issue #1 2017

9 March 2017 | By Drug Target Review

Included in this issue: Importance of building patient trust; Vaccines & Immunology; Oncology; Assays; Biomarkers; and Antibodies...

Developability assessment of therapeutic antibodies

8 March 2017 | By David Matthews (MRC Technology), Lone Friis (MRC Technology)

Developability assessment is a broad term covering the evaluation of potential therapeutic candidates’ drug-like properties, manufacturability and safety profile. It is important to carry out this assessment as early as possible in the pre-clinical stage development to select the candidate with the most stable profile. This can minimise the risks…

Towards systems biomarkers for cancer diagnosis

8 March 2017 | By Francesco Gatto (University of San Diego), Jens Nielsen (Chalmers University of Technology)

Cancer is asymptomatic during most of its pathogenesis. It is very difficult to see that a cancer is growing in a person, except for a few self-evident cases such as skin cancer. Its intangibility and year-, if not decade-long progression make cancer hard to diagnose until some symptoms warrant further…

Whole animal screening: back to the future

8 March 2017 | By Horst Flotow ( Hit Discovery Constance (HDC) GmbH.)

High throughput screening (HTS) has become an integral and productive part of early-stage drug discovery, delivering hits that were the starting points for hit-to-lead programmes and resulting in a number of marketed drugs. HTS can be carried out in a number of formats, ranging from simple biochemical (target-based) to whole…

Christian Andersson, Product Development Manager at Takara Bio

Product Hub: The growing potential of hiPS-derived beta cells

16 February 2017 | By Takara Bio

Christian Andersson, Product Development Manager at Takara Bio discusses hiPS-derived beta cells, which offer an unprecedented opportunity for diabetes research to model human physiology and ‘diseases in a dish’. Christian looks into the potential for new discoveries for diabetes and other metabolic diseases...

Product Hub: Flow cytometric screening assays in drug discovery

16 February 2017 | By Merck KGaA

Flow cytometry is a laser-based technology – a powerful tool for drug discovery and the screening process and can be used in all settings, including research, clinical, pharmaceutical and biotechnology. The increasing capabilities of flow cytometers make their incorporation into drug development and screening optimal...

Democratising clinical genomics while protecting data privacy

1 February 2017 | By Jurgi Camblong (CEO: Sophia Genetics)

Sophia Genetics co-founder and CEO, Jurgi Camblong, tackles issues of privacy and security for healthcare patient data...

How Ketamine could cure depression

30 January 2017 | By Michael Palfreyman PhD DSc (CSO: Amorsa Therapeutics)

Amorsa Therapeutics' CSO, Michael Palfreyman, discusses how the party drug Ketamine can be used to target NMDA receptors and treat depression...

How imaging biomarkers are transforming drug development

15 January 2017 | By Caleb Roberts, John Waterton, Juliana Maynard, Paul Hockings

Drug developers sometimes think of imaging as an emerging discipline, full of esoteric technologies of marginal relevance to real-world clinical drug development. In fact, the opposite is true: imaging measurements (imaging biomarkers) are used daily in drug development and in personalised medicine. They assess target engagement and receptor occupancy in…

Draper and Pfizer partner on human organ-on-a-chip technology

10 January 2017 | By Niamh Marriott (Drug Target Review)

The companies will collaborate to create unique versions of Draper’s Microphysiological Systems (MPS) technology, with the aim of creating more effective disease models...

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