Molecular Targets

New technique speeds up chemical screening

23 August 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed a high-throughput technique that can determine if a chemical has the potential to activate key genes in seconds...

Researchers identify powerful pain reliever

17 August 2017 | By Dr Zara Kassam (Drug Target Review)

A team of scientists  have discovered what they say is a powerful pain reliever that acts on a previously unknown pain pathway...

Tumours detected with sugar molecules

15 August 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have synthesised a complex sugar structure that specifically binds to the tumour protein Galectin-1...

Avenue discovered for precision cancer treatment

2 August 2017 | By Dr Zara Kassam (Drug Target Review)

A novel chemical dubbed "T-REX," along with a patent-pending targeting molecule have uncovered interesting facets of several well-known cancer-cell mutations that, if present in a patient, could inform treatment options and potentially produce more favourable outcomes...

Researchers use CRISPR-Cas9 to target retinal angiogenesis.

25 July 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used CRISPR-Cas9 to target retinal angiogenesis via an adeno-associated virus to deliver genomic edits to target vascular endothelial cell growth factor...

Intracellular target validation in cellular systems … using peptides!

7 July 2017 | By Paul Grant (Venomtech)

Paul Grant from Venomtech suggests that because animal venoms contain proteins and peptides that disrupt cell membrane integrity, they offer a new approach to drug discovery...

Study sheds light on how ovarian cancer spreads

28 June 2017 | By Niamh Marriott (Drug Target Review)

Long-term goal is to develop treatments that prevent cancer cells from attaching to new sites during metastasis.

Collaboration uses novel approach to identify antibacterial drug targets

27 June 2017 | By Drug Target Review

LifeArc, the UK medical research charity previously known as MRC Technology; The Centre for Drug Research and Development (CDRD); and the Defence Science and Technology Laboratory (Dstl), have announced a collaboration to identify antibacterial drug targets.

Snake venom might provide a safer antiplatelet drug

9 June 2017 | By Niamh Marriott (Drug Target Review)

In preliminary research, an antiplatelet drug based on a snake venom protein prevented blood clotting without leading to excessive bleeding, a dangerous side effect of currently available antiplatelet drugs. The venom protein may be the template for a new class of antiplatelet drugs that offers fewer bleeding complications.

The gut microbiota plays key role in diabetes treatment

2 June 2017 | By Niamh Marriott (Drug Target Review)

A clearer picture of how the classic diabetes medication metformin works has emerged.

GE Healthcare Ltd

Flexible new method for early cancer diagnosis

25 May 2017 | By Niamh Marriott (Drug Target Review)

Investments are now being made to roll out this innovation across healthcare and broaden the scope of the research in this field.

DFG €66 million funding for 15 new research training groups

22 May 2017 | By Niamh Marriott (Drug Target Review)

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is establishing 15 new Research Training Groups to further support early research...

Researchers find key molecule that could lead to new anaemia therapies

17 May 2017 | By Niamh Marriott (Drug Target Review)

Researchers find key molecule that could lead to new therapies for anaemia and other iron disorders.

Lung study in mice points to new therapies to treat critical illness

10 May 2017 | By Niamh Marriott (Drug Target Review)

Scientists have pinpointed a chemical signal that worsens inflammation linked to a life-threatening lung condition. The discovery could eventually lead to new therapies for this disease, which can be fatal for up to half of those affected.