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Lipids

news

MIT study reveals how lipid imbalance affects cancer growth in mice

21 October 2021 | By Anna Begley (Drug Target Review)

In a new study, a calorie-restricted diet significantly reduced tumour growth in mouse models, suggesting new possibilities for cancer therapies.

news

Eczema may stem from poorly regulated sex hormones, study finds

20 September 2021 | By Anna Begley (Drug Target Review)

A breaking discovery has revealed the gene HSD3B1 that regulates the production of sex hormones is linked to atopic dermatitis (AD).

news

S1P may be a potential target for cerebral blood alterations

9 September 2021 | By Anna Begley (Drug Target Review)

Sphingosine-1 phosphate was found to regulate blood glow in cerebral blood vessels in mice, presenting a potential therapeutic target.

news

Quantifying method developed to improve neurodegeneration studies

18 August 2021 | By Anna Begley (Drug Target Review)

Researchers have created a new method to quantify protein droplets involved in neurodegenerative diseases, enhancing the study of treatments.

news

CureVac and GSK COVID-19 vaccine shows promise in pre-clinical study

17 August 2021 | By Anna Begley (Drug Target Review)

CureVac and GSK's second-generation mRNA COVID-19 vaccine candidate, CV2CoV, demonstrated improved immune response in a pre-clinical study.

news

Greasy hair proves to be an unexpected possibility for obesity treatment

30 July 2021 | By Anna Begley (Drug Target Review)

Researchers have revealed that the immune system of obese mice treated with TSLP released lipids through sebaceous glands.

news

Very long-chain fatty acids found to block SARS-CoV-2 infection

11 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that omega-3 very long-chain polyunsaturated fatty acids can block SARS-CoV-2 and protect lung cells.

news

Lipid droplets may prevent kidney damage from high-fat diets

17 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown in fruit flies that lipid droplets could prevent the kidney damage that leads to chronic kidney disease.

article

Protecting liposomes in COVID-19 mRNA vaccines could increase their stability

27 April 2021 | By Victoria Rees (Drug Target Review)

A team from the University of Texas at Dallas has shown that a novel buffer solution is effective at stabilising the liposomes and lipid nanoparticles in certain COVID-19 vaccines.

article

Synthesising very long-chain fatty acids to treat retinal conditions

31 March 2021 | By Victoria Rees (Drug Target Review)

A class of lipids – or fatty acids – found in the retina of the eye play an important role in maintaining vision. Victoria Rees, Deputy Editor of Drug Target Review, spoke with Dr Paul Bernstein from the Moran Eye Center at the University of Utah, US, to discover how…

news

Blocking T_reg pathway sensitises mice to immunotherapy

25 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that inhibiting Treg activation in tumours can provide effective immune responses without autoimmune toxicity.

news

PI3K signalling pathway revealed as potential drug target for obesity

18 November 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that the PI3K signalling pathway could be targeted to prevent liptoxicity and combat obesity.

SARS-CoV-2 particles entering human cells

news

Could a sphingosine nasal spray prevent COVID-19?

30 September 2020 | By Hannah Balfour (Drug Target Review)

According to a study, the lipid sphingosine can inhibit SARS-CoV-2 infection and could potentially be delivered in a nasal spray to prevent COVID-19 infections.

news

Pathway to combat chronic myelogenous leukaemia identified in study

24 September 2020 | By Victoria Rees (Drug Target Review)

Researchers have discovered that disrupting the Gdpd3 gene significantly reduced chronic myelogenous leukaemia relapse in mice.

webinar

Drug repurposing approaches to fast track development of new therapies for COVID-19

26 June 2020 | By Tecan

This webinar described the recent efforts to identify small molecule therapeutics for the treatment of SARS-CoV-2 infection and COVID-19 disease.

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Lipids