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Hsp90: Not just a chaperone
Researchers have shown that heat-shock protein 90 acts as a stimulant for exosome release, as well as a protein chaperone...
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Disease research
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Carving a pathway toward personalised cancer therapy
Individualised therapies that target the specific genetic features of tumours have the potential to transform cancer diagnosis, treatment and care. However, several challenges remain before these approaches can be widely used in the clinic.
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Non-antibiotic drug developed to treat TB
Scientists at The University of Manchester have developed the first non-antibiotic drug to successfully treat tuberculosis in animals...
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A new generation of pain relief
Researchers have developed a new generation of pain relief drugs that only target the affected area, with the help of computer simulations...
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Transparent high-resolution EEG array allows brain imaging
Researchers have developed a see-through, dual-layered, mesh EEG device which is capable of measuring the electrical activity of individual neurons...
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New blood test to screen for secondary heart attack
A blood test that quickly and easily detects whether a person is at risk of a secondary heart attack is being developed by scientists at the Baker Heart and Diabetes Institute...
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The rise of high-throughput flow cytometry in drug discovery
Flow cytometry has played a key role in drug development, largely due to its ability to measure up to twenty parameters on single cells or particles suspended in a fluid stream. Typically, cells are labelled with fluorescent markers and passed through a series of lasers, after which the resultant fluorescent…
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Short protein fibres predict the onset and course of Huntington’s disease
A research team has reported that short protein fibres precede the formation of larger deposits that accumulate in the brains of those affected by the incurable Huntington's disease...
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Nuclear PET imaging method developed for tumour detection
Researchers have developed a PET imaging method suitable for many forms of cancer, with high contrast and less inconvenience to patients...
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Tau protein disrupts molecular transport in neurons in Alzheimer’s
Researchers have discovered how the tau protein associated with Alzheimer's affects molecular transport and a nucleporin called Nup98...
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Intervertebral disc degeneration could be treated using mesenchymal stem cells
Researchers explored how mesenchymal stem cells could help to treat intervertebral disc degeneration by accelerating disc matrix remodelling...
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3D liver tissue made from stem cells show promising support of liver function
Stem cells transformed into 3D human liver tissue by scientists show promising support of liver function when implanted into mice with a liver disease...
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Viral DNA mechanism discovery could lead to improved infection control
A new study reveals a previously unknown mechanism that governs whether viruses that infect bacteria will quickly kill their hosts or remain latent inside the cell.
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Making an early link between cognitive impairment and Alzheimer’s
Researchers in the U.S. have devised a novel strategy to effectively identify those individuals with mild cognitive impairment that will most likely go on to develop Alzheimer's disease.
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How challenges including Brexit, inadequate funding & insufficient sample sizes hinder rare disease research
SMi Reports: 8th Annual Orphan Drugs and Rare Diseases Conference to bring together pharmaceutical companies, non-profit organisations and orphan drug developers to explore alliances and facilitate progress.
