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Disease research

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Hsp90: Not just a chaperone

11 September 2018 | By Iqra Farooq (Drug Target Review)

Researchers have shown that heat-shock protein 90 acts as a stimulant for exosome release, as well as a protein chaperone...

news

Carving a pathway toward personalised cancer therapy

11 September 2018 | By Drug Target Review

Individualised therapies that target the specific genetic features of tumours have the potential to transform cancer diagnosis, treatment and care. However, several challenges remain before these approaches can be widely used in the clinic.

news

Non-antibiotic drug developed to treat TB

11 September 2018 | By Drug Target Review

Scientists at The University of Manchester have developed the first non-antibiotic drug to successfully treat tuberculosis in animals...

news

A new generation of pain relief

10 September 2018 | By Drug Target Review

Researchers have developed a new generation of pain relief drugs that only target the affected area, with the help of computer simulations...

news

Transparent high-resolution EEG array allows brain imaging

7 September 2018 | By Drug Target Review

Researchers have developed a see-through, dual-layered, mesh EEG device which is capable of measuring the electrical activity of individual neurons...

news

New blood test to screen for secondary heart attack

7 September 2018 | By Drug Target Review

A blood test that quickly and easily detects whether a person is at risk of a secondary heart attack is being developed by scientists at the Baker Heart and Diabetes Institute...

article

The rise of high-throughput flow cytometry in drug discovery

7 September 2018 | By Conor Fitzpatrick

Flow cytometry has played a key role in drug development, largely due to its ability to measure up to twenty parameters on single cells or particles suspended in a fluid stream. Typically, cells are labelled with fluorescent markers and passed through a series of lasers, after which the resultant fluorescent…

news

Short protein fibres predict the onset and course of Huntington’s disease

6 September 2018 | By Drug Target Review

A research team has reported that short protein fibres precede the formation of larger deposits that accumulate in the brains of those affected by the incurable Huntington's disease...

news

Nuclear PET imaging method developed for tumour detection

6 September 2018 | By Iqra Farooq (Drug Target Review)

Researchers have developed a PET imaging method suitable for many forms of cancer, with high contrast and less inconvenience to patients...

news

Tau protein disrupts molecular transport in neurons in Alzheimer’s

5 September 2018 | By Iqra Farooq (Drug Target Review)

Researchers have discovered how the tau protein associated with Alzheimer's affects molecular transport and a nucleporin called Nup98...

news

Intervertebral disc degeneration could be treated using mesenchymal stem cells

5 September 2018 | By Iqra Farooq (Drug Target Review)

Researchers explored how mesenchymal stem cells could help to treat intervertebral disc degeneration by accelerating disc matrix remodelling...

news

3D liver tissue made from stem cells show promising support of liver function

5 September 2018 | By Drug Target Review

Stem cells transformed into 3D human liver tissue by scientists show promising support of liver function when implanted into mice with a liver disease...

news

Viral DNA mechanism discovery could lead to improved infection control

5 September 2018 | By Drug Target Review

A new study reveals a previously unknown mechanism that governs whether viruses that infect bacteria will quickly kill their hosts or remain latent inside the cell.

news

Making an early link between cognitive impairment and Alzheimer’s

5 September 2018 | By Drug Target Review

Researchers in the U.S. have devised a novel strategy to effectively identify those individuals with mild cognitive impairment that will most likely go on to develop Alzheimer's disease.

news

How challenges including Brexit, inadequate funding & insufficient sample sizes hinder rare disease research

4 September 2018 | By SMi Group

SMi Reports: 8th Annual Orphan Drugs and Rare Diseases Conference to bring together pharmaceutical companies, non-profit organisations and orphan drug developers to explore alliances and facilitate progress.

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Disease research