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CRISPR

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CRISPR method efficiently corrects DMD defect in heart tissue

8 February 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have developed a CRISPR gene-editing technique that can potentially correct a majority of mutations that cause DMD...

news

New to 2018: The role of artificial intelligence in drug discovery

2 February 2018 | By SMi Group

SMi Reports: SMi’s 2nd annual Drug Discovery conference, taking place in London on 21 and 22 March 2018, will discuss the role of artificial intelligence in drug discovery.

news

GalNAc-T6 enzyme selectively up-regulated in colon adenocarcinomas

29 January 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified an enzyme that appears to drive the conversion of normal colon tissue into cancer...

news

Uncovering the early origins of Huntington’s disease using CRISPR engineered embryonic stem cells

29 January 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed a system to model Huntington's in human embryonic stem cells...

news

Researchers create first stem cells using CRISPR genome activation

23 January 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have turned skin cells from mice into stem cells by activating Sox2 and Oct4 using CRISPR technology...

news

CRISPR prevents hearing loss in mice

20 December 2017 | By Steve Bremer (Drug Target Review)

Researchers use CRISPR-Cas9 to target a mutation in the Tmc1 gene that causes the loss of hair cells in the inner ear.

Integrated Drug Discovery Panel – Your questions answered!

article

Q&A: Integrated drug discovery panel – your questions answered

11 December 2017 | By Drug Target Review

Drug discovery from concept to drug candidate has become a collective effort where multi-disciplinary project teams from CROs work with drug companies and academia to deliver clinical candidates, overcoming multi-factorial research obstacles along the way.

news

Charles River adds ERS License to CRISPR/Cas9 service offering

7 December 2017 | By Charles River Laboratories

Charles River Laboratories International, Inc. announced the expansion of its CRISPR/Cas9 service offering with the addition of a license from ERS Genomics Limited.

news

Inhibiting METTL3 destroys AML cells without harming normal blood cells

28 November 2017 | By Dr Zara Kassam (Drug Target Review)

An unexpected drug target for acute myeloid leukaemia could open new avenues to develop effective treatments against the potentially lethal disease...

news

AFM-CRISPR technique used to map DNA mutations

21 November 2017 | By Dr Zara Kassam (Drug Target Review)

Nanomapping technology may transform the way disease-causing genetic mutations are diagnosed and discovered...

news

CRISPR-carrying nanoparticles edit the genome

14 November 2017 | By Dr Zara Kassam (Drug Target Review)

New delivery system deletes disease-causing genes and reduces cholesterol...

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CRISPR-dCas9 reveals surprising insight into breast cancer development

13 November 2017 | By Dr Zara Kassam (Drug Target Review)

Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to become abnormal...

Charles River Laboratories presents newly expanded capabilities at Neuroscience 2017

news

Charles River Laboratories presents newly expanded capabilities at Neuroscience 2017

7 November 2017 | By Charles River Laboratories

Charles River Laboratories International, Inc. announced that its team of neuroscience drug discovery experts is presenting 27 scientific posters, both independently and collaboratively with clients, at Neuroscience 2017, the 47th annual meeting of the Society for Neuroscience (SfN).

news

CRISPR engineered to edit single RNA letters

26 October 2017 | By Dr Zara Kassam (Drug Target Review)

New 'REPAIR' system edits RNA, rather than DNA, without permanently affecting the genome...

news

CRISPR used to identify drug target for bowel cancer

17 October 2017 | By Dr Zara Kassam (Drug Target Review)

CRISPR used to identify a new drug target for bowel cancer that is specific to tumour cells and therefore less toxic than conventional therapies...

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CRISPR