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Therapeutics

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Investigational anti-SARS-CoV-2 molecules show efficacy in pre-clinical studies

8 June 2020 | By Hannah Balfour (Drug Target Review)

Pre-clinical testing of the COVIDTRAP™ (STI-4398) protein and STI-1499 antibody reveal they can inhibit SARS-CoV-2 from infecting cells.

article

TMPRSS2 inhibitors, Bromhexine, Aprotinin, Camostat and Nafamostat as potential treatments for COVID-19

4 June 2020 | By Arsalan Azimi (Shiraz University of Medical Sciences)

Arsalan Azimi explains why inhibiting TMPRSS2 with clinically proven protease blockers could work as a therapeutic strategy against COVID-19.

article

Using pharmacologically-established medicines to treat COVID-19

28 May 2020 | By Kartick Samanta (DECIEM Inc)

A new suggestion has highlighted that the available pharmacologically-established existing medicines should be used to combat COVID-19.

blood vial with 'COVID-19 test' written on it

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Blood test could identify those most at risk from COVID-19

22 May 2020 | By Hannah Balfour (Drug Target Review)

Collaborative research has revealed two hallmarks of COVID-19 infection associated with more severe symptoms that can be identified by a blood test.

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Antibody named S309 from SARS patient shows promise against COVID-19

20 May 2020 | By Victoria Rees (Drug Target Review)

An antibody called S309, identified in a blood sample from a SARS patient, inhibits related coronaviruses, including SARS-CoV-2, researchers have found.

article

Can a computer help us find a treatment for COVID-19?

18 May 2020 | By Victoria Rees (Drug Target Review)

Researchers are utilising computers to aid in their investigations into a COVID-19 treatment. Here, we highlight three studies using simulations, calculations and AI to identify a drug to combat the coronavirus.

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Researchers observe how SARS-CoV-2 changes human cells after infection, revealing drug targets

15 May 2020 | By Victoria Rees (Drug Target Review)

Using mass spectrometry, researchers have shown how human cells are changed by infection from SARS-CoV-2, allowing the team to identify drug targets to prevent viral reproduction.

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Combination of two neutralising antibodies suggested as COVID-19 treatment

14 May 2020 | By Victoria Rees (Drug Target Review)

Two antibodies named B38 and H4 could work as a COVID-19 therapeutic by neutralising the virus, say researchers in China.

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Procedure developed to create murine models of COVID-19 for testing of therapeutics and vaccines

12 May 2020 | By Victoria Rees (Drug Target Review)

Russian researchers have created a process for the development of mouse models for use in pre-clinical studies of COVID-19 treatments and vaccines.

Ticks could hold the answer to COVID-19 treatment

news

Molecules derived from ticks could be used as late-stage COVID-19 treatment

12 May 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that molecules from ticks called Evasins have the potential to halt cytokine storms, the leading cause of COVID-19 fatalities.

news

Multivalent carbohydrate-binding modules show efficacy against COVID-19

8 May 2020 | By Victoria Rees (Drug Target Review)

Tested on plaque reducing assays, researchers have identified a lead candidate multivalent carbohydrate-binding module for the treatment of COVID-19.

news

Researchers identify monoclonal antibody to neutralise COVID-19

5 May 2020 | By Victoria Rees (Drug Target Review)

An antibody that neutralises both SARS-CoV and SARS-CoV-2 in cell cultures has been discovered by researchers and could be used to treat COVID-19.

news

Cytokine storms and T-cell counts may offer clues on COVID-19 treatment

4 May 2020 | By Victoria Rees (Drug Target Review)

According to a new study, treatments for COVID-19 should focus on cytokines and T-cell counts and their function, rather than patient respiratory function.

article

Intravenous immunoglobulins, hyperimmunes and pandemic viruses

4 May 2020 | By Hannah Balfour (Drug Target Review)

David Johnson of GigaGen discusses how recombinant forms of intravenous immunoglobulins (IVIG) could overtake current IVIG therapies and be used in the treatment of COVID-19.

news

Researchers reveal cryo-EM structure of remdesivir bound to SARS-CoV-2

4 May 2020 | By Victoria Rees (Drug Target Review)

A group of researchers has used cryo-EM to discover the structure of the remdesivir-bound RNA complex of SARS-CoV-2 and explain how the drug inhibits COVID-19 viral replication.

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Therapeutics