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Protease inhibitor aprotinin shows promise against SARS-CoV-2 in cells

5 November 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that aprotinin, an approved drug for influenza in Russia, combats SARS-CoV-2 in cells.

cartoon of a blood vessel with coronavirus particles attached to the lining of the vessel and a blood clot formed of red and white blood cells

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Autoantibodies and over-active neutrophils may be cause of COVID-19 blood clots

3 November 2020 | By Hannah Balfour (Drug Target Review)

According to a new study, blood clots in patients with severe COVID-19 are caused by an autoimmune antibody that circulates in the blood and attacks cells.

article

Treating cytokine storms in COVID-19 patients

23 October 2020 | By Dr Fiona McCann (CannBioRx Life Sciences), Dr H Michael Shepard (Enosi Life Sciences), Sir Marc Feldmann (Enosi Life Sciences)

Enosi Life Science researchers Sir Marc Feldmann, Dr H Michael Shepard and Dr Fiona McCann explain why anti-TNF therapies may be effective in treating COVID-19 associated cytokine storms and other inflammatory conditions.

SARS-CoV-2 particles in red over a research background - microscope, connical flask and test tubes in grey

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Severe COVID-19 symptoms may not be caused by cytokine storm

22 October 2020 | By Hannah Balfour (Drug Target Review)

An analysis reveals that in comparison to other inflammatory diseases such as cytokine-release syndrome (CRS) and sepsis, the levels of cytokines in severely ill COVID-19 patients is low.

news

CBD could treat inflammation caused by COVID-19, study shows

20 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that CBD reduces inflammation in the lungs of COVID-19 mouse models by increasing levels of the apelin peptide.

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High doses of favipiravir combat SARS-CoV-2 in hamsters

12 October 2020 | By Victoria Rees (Drug Target Review)

A team showed that high doses of favipiravir can treat hamsters infected with SARS-CoV-2, whereas hydroxychloroquine has no effect.

SARS-CoV-2 particles in grey and red - SARS-CoV-2 is the virus that causes COVID-19

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Researchers suggest blocking factor D protein could combat SARS-CoV-2

9 October 2020 | By Victoria Rees (Drug Target Review)

A team has said that inhibiting the factor D protein could prevent SARS-CoV-2 from turning the immune system against healthy cells.

Syringe drawing liquid from a vial labelled 'REMDESIVIR', on a background of abstract SARS-CoV-2 particles [Credit: ffikretow@hotmail.com / Shutterstock.com].

news

Researchers identify a potential remdesivir resistance mechanism in SARS-CoV-2

8 October 2020 | By Hannah Balfour (Drug Target Review)

Exploring how the Ebola virus develops remdesivir resistance has highlighted a mutation that could allow SARS-CoV-2 to do the same.

SARS-CoV-2 viral particle (which causes COVID-19) circulating in the blood

news

Scientists propose treating SARS-CoV-2 with sofosbuvir and remdesivir

7 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have posited that SARS-CoV-2 could be combatted by sofosbuvir, in combination with other antivirals such as remdesivir.

red viruses pouring out of pink human cell

news

Approved MS medication inhibits SARS-CoV-2 replication in vitro

5 October 2020 | By Hannah Balfour (Drug Target Review)

Dimethyl fumarate (DMF), a multiple sclerosis (MS) drug, inhibited SARS-CoV-2 replication and the hyper-inflammatory immune response associated with COVID-19.

news

SARS antiviral nitric oxide could be used to treat SARS-CoV-2

5 October 2020 | By Victoria Rees (Drug Target Review)

The nitric oxide treatment used during the 2003 SARS epidemic could be used as an antiviral against SARS-CoV-2, researchers say.

SARS-CoV-2 viral particle next to a single RNA strand

news

Novel RNA-targeting molecule can halt SARS-CoV-2 replication

1 October 2020 | By Hannah Balfour (Drug Target Review)

The C5 compound targets the frameshifting element that allows SARS-CoV-2 to effectively replicate and marks the genome for destruction to stop the infection spreading.

SARS-CoV-2 particles entering human cells

news

Could a sphingosine nasal spray prevent COVID-19?

30 September 2020 | By Hannah Balfour (Drug Target Review)

According to a study, the lipid sphingosine can inhibit SARS-CoV-2 infection and could potentially be delivered in a nasal spray to prevent COVID-19 infections.

news

Antibodies from recovered COVID-19 patients inhibit SARS-CoV-2 infection in cells

28 September 2020 | By Victoria Rees (Drug Target Review)

Pre-clinical studies in cells and hamsters have shown that potent antibodies from COVID-19 patients can prevent infection from SARS-CoV-2.

SARS-CoV-2 viral particle in crosshares with words 'target locked' above

news

Experimental antiviral AR-12 could be a promising COVID-19 treatment

23 September 2020 | By Hannah Balfour (Drug Target Review)

Scientists have demonstrated that AR-12 can inhibit SARS-CoV-2 replication and are working to initiate clinical trials evaluating the antiviral drug.

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Therapeutics