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Imaging, sequencing & screening

head and shoulders photo of an adult cynomolgus macaque

news

Cynomolgus macaques: a promising animal model of COVID-19 infection?

17 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers comparing the effects of SARS-CoV-2, SARS-CoV and MERS-CoV in cynomolgus macaques suggest they could be an effective animal model for testing COVID-19 therapeutics.

tablets, capsules and a laboratory scientist in a white coat on a swirling blue background

news

Screening 10,000 compounds identifies six potential COVID-19 therapeutics

17 April 2020 | By Hannah Balfour (Drug Target Review)

High-throughput screening of thousands of compounds has revealed several candidates, including lead compound ebselen, with the potential for treating COVID-19.

news

Celltrion selects 14 lead monoclonal antibodies for COVID-19 treatment

16 April 2020 | By Victoria Rees (Drug Target Review)

After screening 300 antibodies, Celltrion has identified the 14 most powerful that could potentially combat the COVID-19 coronavirus.

drug capsule repelling coronavirus particles

news

COVID-19 Drug Repurposing Database made open-access by Excelra

15 April 2020 | By Hannah Balfour (Drug Target Review)

The enterprise revealed that it has made its COVID-19 Drug Repurposing Database open-access to aid in the search for an effective therapeutic.

Cartoon of people of various races/religions/ethnicities all wearing white surgical masks to protect against COVID-19

news

Researchers release 21 openly available SARS-CoV-2 genome sequences

14 April 2020 | By Hannah Balfour (Drug Target Review)

Austrian researchers reveal the first 21 SARS-CoV-2 viral genomes as part of their project to aid in international understanding of how the virus causing COVID-19 mutates.

news

Main COVID-19 protease revealed, enabling screening of potential drugs

14 April 2020 | By Victoria Rees (Drug Target Review)

Chinese researchers who determined the crystal structure of the COVID-19 protease Mpro used this information to screen over 10,000 compounds to combat the coronavirus.

artist impression of the anatomy of the lungs with bronchi and bronchioles highlighted in red

news

Human lung epithelium model being tested as a platform for COVID-19 research

9 April 2020 | By Hannah Balfour (Drug Target Review)

The developers of the lung epithelium model plan to investigate whether SARS-CoV-2 can infect and replicate in the model to assess whether it could be used in the fight against COVID-19.

news

Receptors enabling COVID-19 infection found on cilia progenitor cells, study shows

8 April 2020 | By Victoria Rees (Drug Target Review)

Sequencing almost 60,000 cells, researchers have found that certain cilia progenitor cells have gene transcripts for ACE2 and co-factor TMPRSS2, enabling COVID-19 infection.

news

Researchers reveal how SARS antibody binds to COVID-19 coronavirus

7 April 2020 | By Victoria Rees (Drug Target Review)

The interaction between a SARS antibody called CR3022 and the COVID-19 coronavirus has been mapped by researchers, revealing a viral vulnerability.

news

AI technology to screen existing drugs for use against COVID-19

2 April 2020 | By Victoria Rees (Drug Target Review)

A collaboration aims to utilise a compound library of 15,000 clinically-ready molecules and screen then against three COVID-19 targets.

news

Novel antiviral compound proposed as COVID-19 therapeutic

30 March 2020 | By Victoria Rees (Drug Target Review)

A molecule called BOLD-100, developed to fight cancer, has been suggested as a therapeutic to combat the COVID-19 coronavirus due to its antiviral properties.

surface of several coronavirus particles

news

COVID-19 viral envelope simulation under development

25 March 2020 | By Hannah Balfour (Drug Target Review)

Researchers are working to build a complete, all-atom model of the exterior of the coronavirus to aid in drug design.

news

UK Consortium to monitor spread and behaviour of coronavirus

24 March 2020 | By Hannah Balfour (Drug Target Review)

The UK government has invested £20 million into the COVID-19 Genomics UK Consortium, which will use whole genome sequencing to inform infection control measures and therapeutic developments.

news

Researchers to screen compound library for antiviral drugs to combat COVID-19

23 March 2020 | By Victoria Rees (Drug Target Review)

Scripps Research has announced it will screen over 14,000 compounds to see if any present significant activity against COVID-19, for use in a therapeutic.

Coronavirus particles in green with purple extracellular proteins

news

Preliminary SARS-CoV-2 protease inhibitor shows efficacy in mice

20 March 2020 | By Victoria Rees (Drug Target Review)

Using X-ray crystallography, researchers have revealed the structure of the SARS-CoV-2 main protease, designing an inhibitor to bind to this target and prevent viral replication.

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Imaging, sequencing & screening