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Novel nanobody combinations protect cells from SARS-CoV-2 in vitro
By combining nanobodies targeting different regions of the SARS-CoV-2 Spike protein, researchers were able to protect cells from infection.
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The Scripps Research Institute (TSRI)
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Could GPCRs be causing people to respond differently to the same drug?
Hannah Balfour explores how genetic variation in G-protein-coupled receptors (GPCRs) and the proteins that regulate the duration of G protein signalling could be contributing to disease and people’s divergent responses to the same therapeutics.
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Novel RNA-targeting molecule can halt SARS-CoV-2 replication
The C5 compound targets the frameshifting element that allows SARS-CoV-2 to effectively replicate and marks the genome for destruction to stop the infection spreading.
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How do general anaesthetics cause loss of consciousness?
Inhaled general anaesthetics have been used for over 100 years and continue to be used daily for surgeries around the world. But how do they induce changes to consciousness? This article explores the research that suggests the anaesthetics chloroform and isoflurane disrupt the organisation of lipid rafts within cellular membranes…
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Could STING activation be the target of future cancer immunotherapies?
Researchers demonstrate that their novel small molecule, which activates the STING protein, supresses tumour growth and metastasis in a murine model of aggressive melanoma.
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Small molecule targeting mRNA could slow the progression of Parkinson’s disease
Research identified a small molecule that targets the mRNA of α-synuclein and prevents the formation of the protein, an approach which could provide novel neurodegeneration therapies.
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Potential treatment path shown for subtype of Charcot-Marie-Tooth disease
A new study could pave the way for developing a viable therapy for Charcot-Marie-Tooth patients affected by TyrRS mutations.
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Unhealthy gut microbiomes in mice remodelled into more healthy ones
Scientists have shown that there are molecules to remodel the gut microbiome and turn an unhealthful gut into a more healthful one for the first time.
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Scientists test new anti-PD-L1 cancer vaccine against melanoma
An experimental cancer vaccine that boosts the immune system's ability to fight cancers could work in tandem with other cancer therapies to fight aggressive tumours, scientists have reported...
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TSRI scientists discover workings of first promising Marburg virus treatment
Scientists at The Scripps Research Institute (TSRI) have discovered the workings of the first promising treatment for Marburg virus, a pathogen with the same pandemic potential as Ebola virus.
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A2aAR protein holds clues for better drug design
Scientists have investigated a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases...
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Faulty gene could be responsible for some Crohn’s disease cases
Interaction between MDR1 gene and TH17 immune cells in the ileum could hold the key to Crohn's disease in some instances.
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dCA accelerates HIV-1 suppression in chronically infected cells
Didehydro-Cortistatin A effectively suppresses production of the HIV virus in chronically infected cells and prevents viral rebound...
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New antibiotic packs a punch against bacterial resistance
Scientists have given new superpowers to an antibiotic called vancomycin, an advance that could eliminate the threat of antibiotic-resistant infections.
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Scientists jump hurdle in HIV vaccine design
Scientists at The Scripps Research Institute (TSRI) have made another important advance in HIV vaccine design.