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Scientists discover promising off-switch for inflammation
Scientists have discovered that itaconate - a molecule derived from glucose - acts as a powerful off-switch for macrophages...
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Harvard Medical School
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Gene manipulation holds the key to personalised medicine
Researchers propose a novel approach to manipulate genes that may hold the key to the future of personalised medicine...
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Blood-vessel-on-a-chip provides insight into new anti-inflammatory drug candidate
Researchers have discovered that synthetic APC-mimicking molecules provide anti-inflammatory and anti-thrombotic protection to endothelial cells without interfering with blood clotting...
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Epigenetic compound inhibits the growth of melanoma cells
Researchers have developed a compound that successfully inhibits the growth of melanoma cells by targeting specific epigenetic modifying proteins...
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CRISPR prevents hearing loss in mice
Researchers use CRISPR-Cas9 to target a mutation in the Tmc1 gene that causes the loss of hair cells in the inner ear.
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Scientists discover a small molecule that halts kidney disease progression
A team of researchers set out to discover the disease pathways of a rare genetic kidney disease and found a compound that stops the disease in its tracks.
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Tumour cell biology reveals characteristic that causes metastasis
A collaborative team of researchers in the US have uncovered characteristics of tumour cells that are linked to cancer metastasis.
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Lung tumours communicate with bones to progress disease
Scientists at Massachusetts General Hospital (MGH) have identified how a type of lung cancer co-opts a portion of the immune system via bone marrow to increase tumour progression.
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Molecular pathway offers treatment targets for pulmonary fibrosis
A study has identified a molecular pathway that appears to be critical to the development of fibrosis...
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Power of radiomics to improve precision medicine
Data mining of medical images with radiomics offers clinicians a way to characterise lung tumours and improve precision medicine...
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Bioprinted veins reveal new drug diffusion details
A scientific collaboration has developed vascularised 3-D bioprinted liver tissue constructs, providing more precise drug toxicity testing...
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New botulinum neurotoxin discovered
Researchers have identified a new toxin, botulinum neurotoxin type X (BoNT/X), that has the potential to open up a new field of toxin therapeutics...
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Lymph node metastases may not always be source of cancer’s spread
A study led has found that the model for the spread of carcinoma - from the primary tumour, to nearby lymph nodes, to other organs - may not apply in all cases.
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New study links neuropilin 2 deficiency to inflammation-induced edema & lymphedema
14 October 2016 | By Niamh Louise Marriott, Digital Content Producer
The Nrp2 knockout mice showed massively increased and prolonged edema following inflammation. Investigation into this finding led Bielenberg's laboratory...
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Interview with Michael Springer, Associate Professor of Systems Biology, Harvard Medical School
17 March 2016 | By Caroline Richards
Caroline Richards, Editor of Drug Target Review, invites Michael Springer, Associate Professor of Systems Biology, Harvard Medical School to discuss a laboratory study of a yeast model using microfluidic systems...
