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Gene identified in zebrafish effective at repairing heart damage

24 October 2019 | By Victoria Rees (Drug Target Review)

Researchers have discovered a gene in zebrafish that enables them to successfully recover after cardiac damage, which could be used to repair heart tissues in humans.

Reasons why targeted immuno-oncology drugs sometimes fail discovered

24 October 2019 | By Rachael Harper (Drug Target Review)

A new study has shown the specific cellular mechanisms that limit the ability of CD8 T cells to infiltrate the tumour microenvironment, which could guide new immunotherapeutic strategies in cancer.

Antibiotics with novel mechanism of action discovered

24 October 2019 | By Rachael Harper (Drug Target Review)

A new family of synthetic antibiotics that possess broad anti-Gram-negative antimicrobial activity has been discovered.

Machine-learning algorithm developed to aid in epigenetic drug discovery

23 October 2019 | By Rachael Harper (Drug Target Review)

A machine-learning algorithm has been created that automates high-throughput screens of epigenetic medicines.

Study reveals how circulating tumour cells target organs

23 October 2019 | By Victoria Rees (Drug Target Review)

Regulator genes and proteins have been identified on circulating tumour cells in mice which allow them to target other organs in the body.

New gene editing tool could correct 89 percent of genetic defects

23 October 2019 | By Rachael Harper (Drug Target Review)

'Prime editing', a new CRISPR genome-editing approach, is capable of directly editing human cells in an accurate and efficient way.

Fullerene compounds could be effective therapy against NSCLC

23 October 2019 | By Victoria Rees (Drug Target Review)

Researchers have used fullerene compounds to cause NSCLC cell death in cell and animal models, which exhibited low toxicity for healthy cells.

Novel therapeutic strategy reverses autism symptoms in mice

22 October 2019 | By Victoria Rees (Drug Target Review)

Researchers have discovered a pathway that causes behavioural abnormalities and other hallmarks of autism; they also revealed how to silence this and reverse the symptoms in mice.

Silencing RNA nanotherapy shows promise in treating pancreatic cancer

22 October 2019 | By Rachael Harper (Drug Target Review)

Peptide-based nanoparticles have been designed which can suppress pancreatic cancer growth without the toxic side effects.

New way to target treatment-resistant cancers identified

22 October 2019 | By Rachael Harper (Drug Target Review)

A new mechanism by which cancer cells become resistant to chemotherapy has been found which could lead to a new target for drugs.

Global consortium formed to combat unproven cell banking services

22 October 2019 | By Victoria Rees (Drug Target Review)

The International Society for Cell and Gene Therapy has created a group to tackle the rising number of commercial cell bank services that are misleading patients.

LVNC congenital heart condition linked to faulty signalling pathway

21 October 2019 | By Rachael Harper (Drug Target Review)

A new study, which has shown that the congenital heart condition LVNC could be be caused by signalling defects, may lead to potential therapies.

Collaborative enzyme study could lead to a target for cancer therapeutics

21 October 2019 | By Rachael Harper (Drug Target Review)

A new study into the enzyme Cdc34 may make it possible to target the enzyme specifically to develop new cancer therapeutics.

Making tumour cells stiff could prevent cancer metastasis

21 October 2019 | By Victoria Rees (Drug Target Review)

A study has demonstrated that the stiffness of cells indicates whether a tumour will spread and inducing this state could help to avoid metastasis.

Researchers create blastocyst-like models from mouse cells

21 October 2019 | By Victoria Rees (Drug Target Review)

Mouse blastocyst-like structures called blastoids have been developed by a team which could be used to study early developmental diseases.

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