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Glioblastoma multiforme

Magnified view of lioblastoma multiforme

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Nanofibre platform shows potential for inhibiting brain tumour growth

22 October 2021 | By Anna Begley (Drug Target Review)

Scientists have created a nanofibre-based sheet to control and direct the migration of cells, possibly leading to brain tumour therapies.

Glioblastoma Multiforme (GBM) cells in culture [Credit: Dr Jin-Min Nam].

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Identifying radioresistance drivers in glioblastoma multiforme

1 October 2020 | By Hannah Balfour (Drug Target Review)

According to researchers, Rab27b and epiregulin contribute to the development of radioresistance and could be targeted to improve glioblastoma patient survival.

pictur of a red brain within the human anatomy with a glowing red mass indicating a brain tumour

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Organoid models for personalised treatments of glioblastomas developed

2 January 2020 | By Hannah Balfour (Drug Target Review)

Lab-grown brain organoids from patients’ glioblastomas could be useful models to rapidly test and identify effective personalised treatments, find researchers.

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Experimental drug combined with radiation extends the survival of GBM

28 June 2018 | By Drug Target Review

A new study has shown that an experimental drug known as AZ32 significantly extends the survival of glioblastoma multiforme, the most common and deadly form of brain cancer...

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Scientists to test Zika virus on brain tumours

19 May 2017 | By Niamh Marriott (Drug Target Review)

The research, using tumour cells in the laboratory and in mice, will see if the Zika virus can destroy cancer cells.

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New counterintuitive approach to treating brain cancer

17 May 2017 | By Niamh Marriott (Drug Target Review)

The loss of the tumour suppressor gene PTEN has been linked to tumour growth and chemotherapy resistance in the almost invariably lethal brain cancer glioblastoma multiforme (GBM).

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Immunotherapy and gene therapy combination shows promise against brain tumours

5 January 2017 | By Niamh Marriott (Drug Target Review)

The outlook for brain tumour patients is pretty negative, with the median survival rate for patients with glioblastoma multiforme, or GBM, a mere 14.2 months.

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Sea sponge reduces pancreatic tumour size

18 August 2016 | By Niamh Louise Marriott, Digital Content Producer

A deep-water marine sponge collected at Fort Lauderdale's coast contains leiodermatolide, a natural product that inhibits the growth of cancer cells as...

SURVIV analysis of breast cancer isoforms

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Biomarkers that could give better cancer survival estimates

9 June 2016 | By Victoria White, Digital Content Producer

A new method, developed by UCLA scientists, could eventually lead to a way to improve accuracy of how well a patient will respond to treatment...

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ReNeuron pursues glioblastoma multiforme as target for exosome platform

9 June 2016 | By Victoria White, Digital Content Producer

ReNeuron selected glioblastoma multiforme based on evidence of tumour-inhibiting activity from early preclinical studies with the exosome technology...

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New study to develop a vaccine for glioblastoma multiforme

2 June 2016 | By Victoria White, Digital Content Producer

Researchers have initiated a new preclinical study aimed at developing a vaccine for the treatment of glioblastoma multiforme using ImmunoBody technology...

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Iceni Pharmaceuticals launches to repurpose cancer therapies

25 May 2016 | By Victoria White, Digital Content Producer

The company’s lead product Cilcane (generic name cilengitide) is being repurposed by Iceni as a first-in-class treatment for multiple myeloma...

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Therapy stops treatment-resistant glioblastoma and high-grade gliomas

9 May 2016 | By Victoria White, Digital Content Producer

In laboratory tests on human cells and mouse models, an experimental therapy was shown to stop treatment-resistant glioblastoma and high-grade gliomas...

Classifying brain tumours to improve diagnoses

article

Classifying brain tumours to improve diagnoses

17 March 2016 | By Xiaolong Fan (Beijing Normal University)

Brain tumours are complex cancer types, arising in many unique forms, each having varying survival rates and differing methods of treatment. Many brain tumours are difficult to clearly diagnose, leading to poor patient prognoses. Although they are mainly diagnosed by analysing morphological appearance, this does not closely correlate with the…

news

PPF could limit the spread of glioblastoma multiforme

13 November 2015 | By Victoria White

PPF works to limit the spread of glioblastoma multiforme by targeting a protein called TROY...

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Glioblastoma multiforme