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Covid-19

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Very long-chain fatty acids found to block SARS-CoV-2 infection

11 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that omega-3 very long-chain polyunsaturated fatty acids can block SARS-CoV-2 and protect lung cells.

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Researchers link SARS-CoV-2 PLpro to COVID-19 symptoms

10 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that the SARS-CoV-2 PLpro cuts human proteins so could potentially cause a range of COVID-19 symptoms.

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Nanoparticle platform enables enhanced delivery of gene therapies

10 June 2021 | By Victoria Rees (Drug Target Review)

Scientists have created new nanoparticle-based materials that could be used to deliver gene therapies in an adaptable way.

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Senolytic drugs reduce COVID-19 symptoms in mice, study shows

9 June 2021 | By Victoria Rees (Drug Target Review)

In pre-clinical studies, senolytic drugs were found to reduce inflammation and death from COVID-19 in older mice.

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Screening identifies existing drugs as potential COVID-19 therapies

8 June 2021 | By Victoria Rees (Drug Target Review)

Scientists have found four clinically approved drugs and nine compounds with the potential to be repurposed as therapeutics for COVID-19.

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TEMPOL drug shows promise as antiviral treatment for COVID-19

8 June 2021 | By Victoria Rees (Drug Target Review)

The experimental drug TEMPOL has demonstrated antiviral activity against COVID-19 in a pre-clinical study in cell cultures.

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SARS-CoV-2 “Mexican variant” sequence analysed by researchers

7 June 2021 | By Victoria Rees (Drug Target Review)

Analysis of one million SARS-CoV-2 genome sequences has revealed a new variant named T478K, spreading mostly in Mexico.

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RT-ddPCR assay developed to quantify regions of SARS-CoV-2 RNA

2 June 2021 | By Victoria Rees (Drug Target Review)

Scientists have created a RT-ddPCR assay to analyse both the non-coding and coding RNA regions of SARS-CoV-2.

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Novel DNA vaccine for SARS-CoV-2 effective in rodent models

1 June 2021 | By Victoria Rees (Drug Target Review)

A new DNA vaccine encoding the SARS-CoV-2 Spike protein has shown promise at protecting mice and hamsters against COVID-19.

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Cross-reactive antibody could form basis of broad coronavirus vaccine

28 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have discovered a cross-reactive coronavirus antibody that could aid in the development of a broad-acting vaccine or treatment.

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Inhaled nanobodies effective against SARS-CoV-2 in hamsters

27 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that inhalable nanobodies at ultra-low doses can effectively neutralise SARS-CoV-2 in hamsters.

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SARS-CoV-2 RNA analysis reveals potential treatment targets

26 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have explored the interaction between SARS-CoV-2 RNA and the host cell, uncovering possible targets to prevent viral replication.

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WHO and Switzerland launch BioHub for pathogen storage and analysis

25 May 2021 | By Victoria Rees (Drug Target Review)

The WHO and Swiss Confederation are set to launch a BioHub Facility, intended to facilitate the sharing of pathogens globally.

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GRP78 molecular chaperone revealed as drug target for COVID-19

25 May 2021 | By Victoria Rees (Drug Target Review)

Using computer modelling, a team has shown that a molecular chaperone called GRP78 could be targeted by drugs in strategies to treat COVID-19.

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Potential SARS-CoV-2 antiviral to be tested in human lung cells

24 May 2021 | By Victoria Rees (Drug Target Review)

A synthetic antiviral named R327 has shown promise in initial tests against SARS-CoV-2 and is now advancing to the next stage of in vitro studies.

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