Assays In-Depth Focus 2018
This Assays In-Depth Focus looks at applications of high content screening in autophagy, and complex biology for the precision medicine era.
In this In-Depth Focus:
- Applications of high content screening in autophagy
Autophagy is an important process to maintain cellular homeostasis and function. Basal levels of autophagy are essential for most cells to remove unwanted protein aggregates and damaged organelles in order to prevent diseases. However, sometimes cells are unable to maintain physiological stability as a consequence of altered autophagy, which leads to various pathological conditions, such as cancer, cardiomyopathies or neurodegenerative diseases. The successful manipulation of autophagy could revolutionise the way we treat these conditions.
- Complex biology for the precision medicine era: re-thinking the drug discovery process
Complex biology is a discipline acknowledging that performing biological experiments in vitro should take account of the complexity of the biological context. While this may be a noble aim, it has proven difficult to incorporate these elements into the drug discovery process, especially at the high-throughput screening (HTS) stage.