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Product hub: Experience flexibility in your primate studies
Save time by measuring 48 immune factors, generating more than 1,800 data points from a single plate, with a small sample volume.
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Merck KGaA
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Synthesising very long-chain fatty acids to treat retinal conditions
A class of lipids – or fatty acids – found in the retina of the eye play an important role in maintaining vision. Victoria Rees, Deputy Editor of Drug Target Review, spoke with Dr Paul Bernstein from the Moran Eye Center at the University of Utah, US, to discover how…
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Expert view: Challenges in drug discovery screening
The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
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Assays In-Depth Focus 2018
This Assays In-Depth Focus looks at applications of high content screening in autophagy, and complex biology for the precision medicine era.
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Expert view: Managing the complexity of finding new targets and drugging the undruggable
Assessing targets that are unable – or rather, extremely difficult – to reach pharmacologically, has prevented researchers from achieving desired clinical successes, most notably in the realm of cancer research. However, many advances are being made to shedlight on these difficult yet desirable target areas.
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Application note: Analyte quarterly Vol 1
Your comprehensive guide to multiplex and single protein detection...
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Expert view: Improving R&D productivity with novel screening approaches
The pursuit of improved R&D productivity rates coupled with decreased cycle times has dominated pharmaceutical discourse in recent years.
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Screening In-Depth Focus 2018
This In-Depth Focus reviews the history of cancer treatments, looks at improving the translation of disease biology though phenomics, and considers how to enhance cell bioprocessing through cell-based combinatorial culture.
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How the study of lipidomics is benefiting from recent advances in mass spectrometry
There are no short-cuts in the complex field of lipidomics, explains Cristina Legido-Quigley, a Principal Investigator in Systems Medicine at Steno Diabetes Center Copenhagen in Denmark and at King’s College London.
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Expert view: Screening tools for better lead characterisation
Predictiveness is one of the key factors for success in the drug discovery workflow. Many compounds fail at late stages due to lack of predictive data or the discovery of unwanted side effects.
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Poster: Expansion of human induced pluripotent stem cells in scalable stirred suspension culture
12 January 2018 | By MilliporeSigma
Expansion of hiPSCs as aggregates in stirred suspension...
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Poster: Expansion of human induced pluripotent stem cells in scalable stirred suspension culture
12 January 2018 | By Merck
Expansion of hiPSCs as aggregates in stirred suspension...
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Expert view: Conquering late stage failures with advanced hit-to-lead techniques
Failing early in drug discovery is the primary driving force for new techniques in the hit-to-lead phase.
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Scientific article: iPSC Cells
An entirely new area of stem cell biology was introduced by Shinya Yamanaka in 2006 when he discovered that somatic cells could revert back to pluripotent-like cells, or induced pluripotent stem cells (iPSCs).
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Hit To Lead In-Depth Focus 2017
In this In-Depth Focus we look at a pragmatic approach to hit validation following biochemical high-throughput screening as well as identification of hits and leads for human African trypanosomiasis.
