Application note: Understanding Cell Death by High Content Analysis

Cell death is a process that occurs as both a part of normal tissue homeostasis and can be aberrantly regulated in some disease states, specifically cancer.

Cell catabolism occurs primarily by one of three mechanisms: Apoptosis, Autophagy and Necrosis. Each of these mechanisms has several specific morphological and biochemical characteristics from which it can be identified. In addition, apoptosis, autophagy and necrosis serve specific functions in both normal and diseased cellular states.