Carlos le Sage, Manager – Manager of the Functional Genomic Screening Platform, Horizon Discovery
Carlos is Manager of the Functional Genomic Screening Platform at Horizon Discovery. His research focuses mainly on discovering novel resistance and sensitivity
mechanisms of cancer cells exposed to newly-developed compounds. He has many years of experience in the development and use of functional genomic techniques, initially with RNAi and more recently with CRISPR gene modifying and modulating technologies for genome-wide loss- and gain-of-function screening.
Since joining Horizon Discovery, Carlos has engaged in a large number of client-based projects centred on functional genomics. He received the Trailblazer Award for his involvement in developing and providing CRISPR activation and interference genome-wide screen technologies as off-the-shelf services in 2017. Prior to joining Horizon Discovery, Carlos completed postdoctoral research with Steve Jackson at the Gurdon Institute in Cambridge. He holds a PhD in biology from the Netherlands Cancer Institute through Leiden University.
