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Target Validation

Improving drug discovery with advanced targeted proteomic monitoring workflows

30 September 2021 | By Dr Lauren Stopfer (BioNTech), Professor Forest White (MIT)

In this article, Professor Forest White, Department of Biological Engineering at MIT, and Dr Lauren Stopfer, Scientist at BioNTech, present a novel assay approach for the rapid, reproducible and accurate identification of potential therapeutic targets using mass spectrometry.

article

Targeting disease pathways to treat ulcerative colitis – beyond corticosteroid use

29 September 2021 | By Dr Chetan Karyekar (Janssen)

Dr Chetan Karyekar, Compound Development Team Leader at The Janssen Pharmaceutical Companies of Johnson & Johnson (J&J), explains how targeting underlying immune pathways can open the door to effectively treating more inflammatory bowel disease (IBD) patients by reducing or eliminating the chronic use of corticosteroids.

White pills on black surface with COVID-19 structure drawn on

news

Scientists uncover mechanisms of potential COVID-19 drug targets

28 September 2021 | By Anna Begley (Drug Target Review)

Researchers have used CRISPR and cryogenic electron microscopy to unravel the workings of two receptors involved in diseases such as cancer and COVID-19.

Woman holding stomach in pain next to scan of uterus

news

NPSR1 gene discovered as a key cause of endometriosis

31 August 2021 | By Anna Begley (Drug Target Review)

NPSR1 has been identified as a genetic cause of endometriosis, revealing a potential drug target that may lead to better therapies.

news

Signalling pathway identified as target against paediatric glioma

25 August 2021 | By Anna Begley (Drug Target Review)

Researchers have found a vulnerability in a developmental signalling pathway, presenting a target for paediatric low-grade glioma formation.

news

Nanosized molecules inhibit formation of plaques related to Alzheimer’s

5 July 2021 | By Victoria Rees (Drug Target Review)

In brain tissues, researchers have shown that two different nanosized polyoxoniobate molecules can inhibit the assembly of amyloid plaques.

news

Study of liver cancer reveals MAGEA3 gene as new drug target

25 June 2021 | By Victoria Rees (Drug Target Review)

A study has shown that blocking the gene expression of MAGEA3 in liver cancer cells prevents the tumour from proliferating.

news

Nanodecoy therapy neutralises SARS-CoV-2 in macaques

18 June 2021 | By Victoria Rees (Drug Target Review)

Lung spheroid cells can act as nanodecoys for the SARS-CoV-2 Spike protein to bind to, according to a new pre-clinical study.

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New approach for treating cystic fibrosis shows success in mice

17 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a potential strategy to treat cystic fibrosis, using oligonucleotides to correct certain gene defects.

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Targeted drug found to combat certain pancreatic tumours

15 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have found that the CDK inhibitor AT7519 could be used to treat pancreatic cancer patients whose tumours are addicted to mutant KRAS.

news

Potential ovarian cancer treatment proves effective in pre-clinical studies

14 June 2021 | By Victoria Rees (Drug Target Review)

A new radiopharmaceutical compound has shown success at treating ovarian cancer in mice and in vitro studies.

news

Molecules from resin combat epileptic seizures in pre-clinical studies

9 June 2021 | By Victoria Rees (Drug Target Review)

Drug molecules from pine and spruce trees can affect certain ion channels and had antiseizure effects in pre-clinical studies.

news

TEMPOL drug shows promise as antiviral treatment for COVID-19

8 June 2021 | By Victoria Rees (Drug Target Review)

The experimental drug TEMPOL has demonstrated antiviral activity against COVID-19 in a pre-clinical study in cell cultures.

news

Newly identified protein could become target for cancer immunotherapy

7 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have found a protein that, when inhibited in mice with cancer, increased the response to immunotherapy.

news

Researchers identify how to potentially prevent cancer metastases

3 June 2021 | By Victoria Rees (Drug Target Review)

Scientists have discovered that hepatic stellate cells are key in allowing dormant cancer cells to awaken and form fatal metastases.

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Target Validation