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t-cells

diabetic person using pre-filled syringe to inject their stomach with insulin

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Genetic deletion permanently prevented type 1 diabetes development in mice

30 March 2020 | By Hannah Balfour (Drug Target Review)

Researchers observed that deleting the IRE1-alpha gene caused beta cells to de-differentiate and then re-differentiate in mice, preventing immune system auto-activation.

news

Collaboration initiated to develop COVID-19 immunotherapy

26 March 2020 | By Victoria Rees (Drug Target Review)

The University of Georgia and CEL-SCI Corporation have partnered to develop an immunotherapy to combat the COVID-19 coronavirus using the Ligand Antigen Epitope Presentation System (LEAPS) technology.

Human tuberculosis blood signal replicated in mice

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Human tuberculosis blood signal replicated in mice

24 March 2020 | By Rachael Harper (Drug Target Review)

More research into tuberculosis is now possible with the development of an optimisied mouse model that exhibits the same blood immune response to Mycobacterium tuberculosis infection as humans.

news

Early natural killer cells more effective than adult versions, find researchers

24 March 2020 | By Victoria Rees (Drug Target Review)

Researchers have shown that natural killer (NK) cells work best as an immunotherapy when in an early stage of development, so could be manufactured from pluripotent stem cells.

whitepaper

Application note: Immuno-oncology

20 March 2020 | By Bio-Techne

Identifying next generation targets for cancer immunotherapy.

news

Interleukin-2 interactions revealed by researchers to aid in drug design

18 March 2020 | By Victoria Rees (Drug Target Review)

Using nuclear magnetic resonance spectroscopy, a study has shown that IL-2 can stimulate both effector T cells and regulatory T cells by adopting different structural forms.

whitepaper

Application note: Tools for cell therapy and immunoregulation

17 March 2020 | By Bio-Techne

Multiple co-signalling molecules regulate T cell activation.

coronavirus particle with man with face mask on

news

Researchers work to create a COVID-19 viral epitope map

13 March 2020 | By Hannah Balfour (Drug Target Review)

The team used data from SARS-CoV to identify possible viral epitopes that vaccines could include to stimulate an immune response.

news

Increasing ion channel function in cancer T cells could be new immunotherapy

11 March 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that there is less calmodulin binding to ion channels in the T cells from cancer patients, presenting a new immunotherapeutic target.

news

T-cell regulator SLAMF6 may be hindering immunotherapy success

5 March 2020 | By Mandy Parrett (Drug Target Review)

A new study conducted in Israel suggests that T cells’ ability to destroy skin cancer increases in the absence of T-cell regulators called SLAMF6.

news

Mitochondria-boosting compound promotes immunotherapy in mice

4 March 2020 | By Victoria Rees (Drug Target Review)

Researchers have discovered that a small molecule can help some T cells combat tumours during PD-1 blockade immunotherapy in mice.

tablets, syringes and drug vials surrounding the words 'autoimmune disease'

article

Rebalancing the immune system to treat autoimmune disease

2 March 2020 | By Hannah Balfour (Drug Target Review)

Dr Nicolas Poirier reveals how immunotherapies can be designed to recalibrate the immune system for long-term maintenance of autoimmune remission.

news

New T-cell discovery could lead to treatments for both bacterial infections and autoimmune conditions

28 February 2020 | By Hannah Balfour (Drug Target Review)

A novel highly activated form of T cells could be suppressed to treat autoimmune conditions and activated in treating bacterial infections.

news

Researchers generate atlas of thymus to understand T-cell development

25 February 2020 | By Victoria Rees (Drug Target Review)

A new study has created an atlas of human thymus development, to reveal which genes are needed for the production of specific T cells.

news

Using blue light to control CAR T cells and destroy tumours

21 February 2020 | By Victoria Rees (Drug Target Review)

Researchers have created a method to activate CAR T cells with blue LED light to successfully combat solid tumours in mice.

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