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Stem Cells

Stem cells are undifferentiated biological cells that can differentiate into specialised cells and can divide to produce more stem cells.

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New cell separator could advance cancer and Alzheimer’s research

8 May 2017 | By Niamh Marriott (Drug Target Review)

A new cell separator that began life as a tinfoil and epoxy glue prototype built with supplies from a University shop could revolutionise stem-cell and regenerative cell-based therapies.

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New chlamydia drug targets discovered using CRISPR and stem cells

8 May 2017 | By Niamh Marriott (Drug Target Review)

Scientists have created an innovative technique for studying how chlamydia interacts with the human immune system...

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Researchers identify potential Zika Virus target

5 May 2017 | By Niamh Marriott (Drug Target Review)

New research provides insights into why infection with Zika virus after birth generally causes only mild symptoms, whereas devastating foetal malformations can develop when infection occurs during pregnancy.

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Cancer-causing virus masters cell’s replication & immortality

4 May 2017 | By Niamh Marriott (Drug Target Review)

Viruses are notorious for taking over their host's operations and using them to their own advantage. But few human viruses make themselves quite as cozy as the Epstein-Barr virus, which can be found in an estimated 9/10 humans without causing any ill effects. That is, until this virus causes mononucleosis…

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Researchers print stem cells using 3D bioprinter to form cartilage

2 May 2017 | By Niamh Marriott (Drug Target Review)

A team of researchers have generated cartilage tissue by printing stem cells using a 3D-bioprinter...

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Removing old cells could extend joint health & stop osteoarthritis

27 April 2017 | By Niamh Marriott (Drug Target Review)

In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.

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Scientists uncover mechanism allowing bacteria to survive the human immune system

20 April 2017 | By Niamh Marriott (Drug Target Review)

Researchers have uncovered molecular details of how pathogenic bacteria fight back against the human immune response to infection.

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Plasticell and Kings College London to collaborate in trials of blood platelet substitute

20 April 2017 | By Niamh Marriott (Drug Target Review)

Over 10 million units of platelets are transfused worldwide each year in one of the most common procedures in clinical medicine. However, platelets derived from human donors can transmit infections and trigger serious immune reactions that eventually render the therapy ineffective (a condition known as alloimmune refractoriness). In addition, since…

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Plasticell to produce red blood cell substitute from pluripotent stem cells

18 April 2017 | By Niamh Marriott (Drug Target Review)

Over 90 million blood transfusions are carried out worldwide each year and alternative sources to donor-derived blood are being sought to meet rising demand. In addition there is a need to secure a safer supply of blood products, chiefly in developing countries where there is a relatively higher risk of…

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Premature cell differentiation leads to disorders in pancreatic development

12 April 2017 | By Niamh Marriott (Drug Target Review)

Neonatal diabetes mellitus (NDM), or diabetes among infants less than six months of age, is a rare form of diabetes caused by a mutation in genes crusial to the development or function of beta cells. In about half of such cases, the disease becomes permanent (PNDM). Mutations in more than…

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Stem cell patch shows early promise in treating heart failure

6 April 2017 | By Niamh Marriott (Drug Target Review)

In a Phase I clinical trial, heart failure patients treated with patches made from their muscle cells showed improved exercise capacity and heart function after one year. Stem cell patch-based therapy may be a viable heart failure therapy and should be validated in larger clinical trials, researchers conclude.

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New gene discovered drives cancer drug resistance

4 April 2017 | By Niamh Marriott (Drug Target Review)

Scientists in Salford, UK, have identified a gene which is ‘revving the engine of cancer’ against the world’s most common breast cancer drug.

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Plasticell signs stem cell research collaborations with Singapore academia

31 March 2017 | By Niamh Marriott (Drug Target Review)

Plasticell, a developer of stem cell technologies and cell-based therapies, has signed agreements with the Agency for Science, Technology and Research (A*STAR) and the Nanyang Technological University (NTU) to progress its therapeutic stem cell pipeline.

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Research into genome reorganisation sheds light on epigenetic reprogramming

29 March 2017 | By Steve Bremer (Drug Target Review)

Researchers have shed light on genome reorganisation occurring during the first hours post-fertilisation in a single-cell mammalian embryo

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Study shows potential of stem cell therapy to repair lung damage

28 March 2017 | By Niamh Marriott (Drug Target Review)

A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Although, still at a pre-clinical stage, these findings have important potential implications for the future treatment of patients.

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Stem Cells