Protein

Single enzyme provides target for new sepsis drugs

14 August 2019 | By Rachael Harper (Drug Target Review)

Researchers have discovered that removing the enzyme, PHLPP1, improves outcomes in a mouse model of sepsis so could be a potential drug target.

Blood-brain barrier role in Alzheimer’s patients revealed by tissue model

13 August 2019 | By Rachael Harper (Drug Target Review)

A new study has found that damage caused by Alzheimer's allows toxins to enter the brain, further harming neurons.

Parkinson’s disease symptoms “improved” by oestrogen

13 August 2019 | By Rachael Harper (Drug Target Review)

New research into sex-based differences of Parkinson's disease could lead to new treatments.

Direct toxic action of beta-amyloid in Alzheimer’s patients identified

12 August 2019 | By Rachael Harper (Drug Target Review)

The cause and trigger of the large clumps of protein beta-amyloid found in the brains of early-stage Alzheimer's patients have been discovered.

Therapeutic target for Kennedy’s disease and prostate cancer proposed

9 August 2019 | By Rachael Harper (Drug Target Review)

A chaperone protein has been identified as a possible therapeutic target for the treatment of Kennedy's disease and prostate cancer.

Potential treatment target identified for Crohn’s disease

9 August 2019 | By Rachael Harper (Drug Target Review)

Researchers have identified a pathway in the immune system activated in Crohn's disease which could lead to investigating new treatments.

Researchers grow genetically engineered mini livers to study disease

6 August 2019 | By Rachael Harper (Drug Target Review)

The first genetically modified mini human livers have been grown in a laboratory, to emulate liver disease progression and test therapeutics.

Experimental treatment slows prion disease

5 August 2019 | By Rachael Harper (Drug Target Review)

A new experiment has not only slowed the progression of the prion disease, scrapie, it also extended the lives of prion-infected mice

Protective protein guards against DNA damage

5 August 2019 | By Rachael Harper (Drug Target Review)

It has been discovered that Polo-like kinase (PLK1) guards against severe DNA damage and could help target fast-growing cancer cells.

Antibody therapy extends survival in mice with pancreatic cancer

1 August 2019 | By Rachael Harper (Drug Target Review)

Scientists have found a way to target and knock out a protein which is widely involved in pancreatic cancer cell growth, survival and invasion.

Cancer cell nutrient pathway mechanism discovered

1 August 2019 | By Victoria Rees (Drug Target Review)

Researchers have discovered the mechanism behind a gateway into cells for glutamine, illuminating potential ways to prevent cancer cells from getting nutrients.

Newly discovered signal could lead to anti-cancer therapies

31 July 2019 | By Drug Target Review

Researchers have newly found that protein CD24 acts as a defensive signal and is used by cancer cells to protect themselves.

New discovery could lead to new treatments for Parkinson’s

30 July 2019 | By Drug Target Review

New discovery makes it possible to design new therapies to replace alpha-synuclein's function in people with Parkinson's disease.

Enzo Life Sciences

Scientists control living cells using artificial protein switch

24 July 2019 | By Drug Target Review

Scientists have created the first completely artificial protein switch that can be ‘programmed’ to modify gene expression.