news
S1P may be a potential target for cerebral blood alterations
Sphingosine-1 phosphate was found to regulate blood glow in cerebral blood vessels in mice, presenting a potential therapeutic target.
List view / Grid view
Neurosciences
news
Innovative brain model provides patient-specific Alzheimer’s insights
Researchers have turned human stem cells into brain cells to create a new model that can predict cognitive decline rate on an individualised level.
news
DNA mechanism discovery may open up Huntington’s disease therapies
Scientists unveiled how a DNA repair protein may prevent Huntington’s disease, presenting a new target in future therapies.
article
Delivering gene therapies to the brain to treat Alzheimer’s
Dr Ronald G Crystal, Professor and Chairman of the Department of Genetic Medicine, Weill Cornell Medical College, spoke to Drug Target Review’s Victoria Rees about his research into Alzheimer’s disease and why gene therapies represent a promising area of research for neurodegenerative conditions.
news
Multi-omics approach identifies genes associated with alcohol use disorder
First-of-its-kind study uses a multi-omics approach to provide a list of causal candidate genes associated with alcohol use disorder (AUD).
article
Getting “under the skin” of frontotemporal dementia
Researchers at the University of East Finland have been using skin cells to investigate pathological hallmarks in frontotemporal dementia patients.
news
Mechanisms behind synapse degeneration in Alzheimer’s unveiled
Researchers have uncovered a signalling pathway associated with glutamatergic synapse degeneration in the brains of mice with Alzheimer’s.
news
New study discovers how Parkinson’s-linked protein attacks mitochondria
Researchers have used fruit fly larvae to explore how alpha-synuclein impacts the mitochondria, advancing the study of Parkinson’s disease.
news
Genome-editing strategy may become novel Alzheimer’s treatment
Scientists have developed a new strategy using brain-wide genome-editing technology that reduced Alzheimer’s disease pathologies in mice.
news
Quantifying method developed to improve neurodegeneration studies
Researchers have created a new method to quantify protein droplets involved in neurodegenerative diseases, enhancing the study of treatments.
news
TREM2 regulation to prevent neurodegeneration is possible, study shows
Scientists used a synthetic thyroid hormone in mice to regulate the TREM2 gene implicated in diseases such as Alzheimer’s and Parkinson’s.
news
Uncovering ketamine’s mechanisms helps identify depression treatment
A new study has revealed how ketamine exerts its antidepressant effect, raising hopes of finding new treatment options for the disease.
news
Key hallmark of ALS is successfully reversed in laboratory
Scientists demonstrated how to reverse the incorrect localisation of three RNA-binding proteins in ALS, potentially leading to treatments.
news
Prize winner uncovers how microbiome can combat neurodegeneration
Eran Blacher has won the NOSTER & Science Microbiome Prize for discovering the link between the microbiome and neurodegenerative diseases.
news
Mitochondria repair in mice may provide answers on Parkinson’s disease
Researchers used an experimental small molecule that helped restore the removal of damaged mitochondria from brain cells in a mouse model of Parkinson's.
