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microRNA

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Nanoparticles give disease-fighting properties to cells

30 August 2017 | By Dr Zara Kassam (Drug Target Review)

A new biomedical tool has been developed using nanoparticles that deliver transient gene changes to targeted cells...

news

Researchers find switch that turns on immune cells tumour-killing ability

17 August 2017 | By Dr Zara Kassam (Drug Target Review)

Researcher have shown how a mRNA molecule known as Lethal-7 serves as a molecular control hub to direct the function of cytotoxic T lymphocytes...

news

New cancer therapy eliminates toxic delivery vehicles for mRNA

2 August 2017 | By Dr Zara Kassam (Drug Target Review)

US researchers have conjugated RNA to a molecule of folate, the folate receptor is overexpressed on cancer cells but very low on normal cells, which is why they can target a tumour and avoid healthy cells...

news

New study reveals new drug target for gout & inflammatory diseases

7 July 2017 | By Niamh Marriott (Drug Target Review)

Research reveals cathepsins as potential therapeutic targets in particulate-mediated inflammatory disease…

news

Pathways leading to beta cell division identified, may aid diabetes treatment

4 May 2017 | By Niamh Marriott (Drug Target Review)

Pancreatic beta cells help maintain normal blood glucose levels by producing the hormone insulin -- the master regulator of energy (glucose). Impairment and the loss of beta cells interrupts insulin production, leading to type 1 and 2 diabetes.

news

microRNA reduces stroke risk

3 May 2017 | By Niamh Marriott (Drug Target Review)

The molecule microRNA-210 stabilises deposits in the carotid artery and can thus prevent them from tearing, and prevent dangerous blood clots from forming.

news

Update on Charles River’s collaboration with Moderna Therapeutics

30 January 2017 | By Charles River Laboratories

Charles River Laboratories has provided a progress update related to its support of Moderna Therapeutics’ nonclinical discovery and development efforts...

news

EBV-derived microRNAs silence immune alarm signals of the host cell

5 October 2016 | By Niamh Louise Marriott, Digital Content Producer

The virus drives production of small molecules, so-called microRNAs, which suppress alarm signals sent out by the infected cell...

article

Moderna discuss mRNA therapeutics in cystic fibrosis

22 July 2016 | By Victoria White, Digital Content Producer

Drug Target Review recently caught up with Lorence Kim, Chief Financial Officer of Moderna, to find out more about the company‘s collaboration with Vertex and using mRNA therapeutics to treat patients with cystic fibrosis...

news

Vertex and Moderna to develop cystic fibrosis mRNA Therapeutics

6 July 2016 | By Victoria White, Digital Content Producer

Their collaboration will focus on the use of mRNA therapies to enable cells in the lungs to produce functional copies of the CFTR protein...

news

Ethris publishes mRNA therapy musculoskeletal regeneration data

21 March 2016 | By Victoria White

Ethris has announced the publication of data that underlines the broad therapeutic potential of the company’s proprietary mRNA transcript therapy platform...

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