List view / Grid view
High-content screening (HCS) approaches have become increasingly common in drug discovery with HCS technologies integrated across the drug discovery pipeline. Here we discuss recent developments in this arena.
In this in-depth focus, the challenges of imaging are explored including how to develop high-resolution images. Also discussed are new imaging technologies to aid drug discovery.
Image-based phenotypic profiling of small molecules has been used for identification and characterisation of small molecules in drug discovery and can provide important insights into their mechanisms of action (MOA). This article discusses the use of phenotypic profiling in drug discovery and how machine-learning algorithms could help improve objectivity, processing…
In this issue: novel approaches to produce radiolabelled antibodies, the use of CRISPR/Cas9 to accelerate the development of targeted therapies and utilisation of stem cells to study the effects of cannabis on neuronal development.
Nuclear magnetic resonance measurement and state-of-the-art computational science reveal protein structures in higher eukaryotic cells.
A new method of assessing the actions of medicines by matching them to their unique protein receptors could accelerate drug development.
Findings from a recent study could lead to the development of therapeutic approaches against influenza A viruses.
Researchers have developed a new technology that allows them to probe cell changes without disturbing the cell’s physiology.
Researchers from the University of Zurich have created a new method for radiolabelling antibodies using UV light - with proteins being ready-to-use for cancer imaging or therapy in less than 15 minutes.
A method of imaging using longer wavelengths could mean that tiny tumours and clusters of cancer cells may be detected earlier than current methods allow...
A method of imaging calcium activity that is based on magnetic resonance imaging (MRI) could help to image deep within the brain...
The team used techniques used by physicists along with highly specialised equipment to investigate deep into the bacterial membrane...
Researchers have developed a method using PET imaging along with 18F-fluorofuranylnorprogesterone to analyse the efficacy of breast cancer treatments...
Researchers have created a tool that would help detect Alzheimer’s disease in its most incipient stages...
A method developed to look into capillaries could give insight into this central portion of the human circulatory system, and be used as a diagnostic tool...
