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Gene testing

Gene testing is a type of medical test that identifies changes in chromosomes, genes, or proteins.

Man holding paper with DNA molecule breaking apart, representing gene editing

news

Moderna and Metagenomi to develop in vivo gene therapies

3 November 2021 | By Anna Begley (Drug Target Review)

Moderna and Metagenomi have announced a collaboration to jointly create next-generation in vivo gene editing therapeutics.

CRISPR Cas9 protein and DNA molecules, 3D gene therapy rendering

article

CRISPR-Cas9-based gene dropout screens: a powerful platform for drug discovery

23 September 2021 | By Dr Pushpanathan Muthuirulan (Harvard University)

CRISPR holds great promise in advancing pharmacological research and has fuelled the rapid expansion of using gene-edited cells for drug discovery processes. CRISPR-Cas9 dropout screens have emerged as a useful tool for high-throughput large-scale loss-of-function screens, which seek to identify the relationship between genotype and phenotype. Dr Pushpanathan Muthuirulan, Research…

Application note: Streamlined genome engineering in picodroplets

whitepaper

Application note: Streamlined genome engineering in picodroplets

23 September 2021 | By Sphere Fluidics Ltd.

A picodroplet-based microfluidic method for automating the complete genome-editing workflow. Learn more in this free application note.

news

Scientists create organoid biobank to study SARS-CoV-2 genes

20 September 2021 | By Anna Begley (Drug Target Review)

Researchers have established an organoid biobank to search for genes that are essential for the spreading of SARS-CoV-2 infection.

Doctor with technology showing DNA and drug pills

news

Novel technology could significantly advance genomics field

16 September 2021 | By Anna Begley (Drug Target Review)

New technology system of drug-based markers for the selection or counter-selection of genes may advance genetic screening methods.

news

Scientists reveal that glioblastoma shows dependency on biotin distribution

15 September 2021 | By Anna Begley (Drug Target Review)

Researchers discovered that glioblastoma cells rely on biotin distribution for growth, leading to possible future drug combinations.

news

Researchers identify novel genomic marker of childhood leukaemia

23 August 2021 | By Anna Begley (Drug Target Review)

A team have found that two DNA changes appear to predict acute lymphoblastic leukaemia, illuminating genetic understanding of the disease.

news

TREM2 regulation to prevent neurodegeneration is possible, study shows

13 August 2021 | By Anna Begley (Drug Target Review)

Scientists used a synthetic thyroid hormone in mice to regulate the TREM2 gene implicated in diseases such as Alzheimer’s and Parkinson’s.

news

Researchers reveal potential cause of COVID-19 aftereffect in children

13 August 2021 | By Anna Begley (Drug Target Review)

Scientists have uncovered an important clue to the COVID-19-related multisystem inflammatory syndrome in children (MIS-C).

news

Molecular insights into LSCC may lead to new drug targets

10 August 2021 | By Anna Begley (Drug Target Review)

New insights into lung squamous cell carcinoma (LSCC) have emerged from a proteogenomic study, leading to the identification of potential drug targets.

news

Therapeutic target for aggressive cancers discovered through CRISPR

5 August 2021 | By Anna Begley (Drug Target Review)

The RNA-modifying protein METTL1 could be targeted to treat some types of aggressive cancers, including brain, blood and kidney.

news

Mitochondria repair in mice may provide answers on Parkinson’s disease

4 August 2021 | By Anna Begley (Drug Target Review)

Researchers used an experimental small molecule that helped restore the removal of damaged mitochondria from brain cells in a mouse model of Parkinson's.

news

Defective proteins found to be potential targets for Alzheimer’s treatments

12 July 2021 | By Anna Begley (Drug Target Review)

US researchers have identified potential new treatment targets for Alzheimer’s disease, as well as existing drugs that could be used against these targets.

webinar

CRISPR screening to identify new drug targets in regulatory B cells and other immune cells

15 January 2021 | By Horizon Discovery

Watch our on-demand webinar where we discuss how CRISPR screening is proving to be a robust platform for the identification and validation of new biological targets for disease treatment. It is hoped that CRISPR screens will accelerate drug development by providing more robust targets for validation than siRNA screens, for…

article

Genetic screening to predict the risk of future diseases

2 December 2020 | By Dr Pushpanathan Muthuirulan (Harvard University)

The use of genetic testing has had a positive impact on patient care, bringing abundant opportunities for diagnosis or predictions of future diagnoses. Pushpanathan Muthuirulan explains how the application of genetic screening can help to customise healthcare for individuals based on their unique genetic makeup.

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Gene testing