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Promising preclinical drug candidate suppresses HIV
A team of researchers have tested a chemical compound that suppresses HIV, protects immune cells, and remains effective for weeks with a single dose...
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Anti-obesity drug shrinks fat without suppressing appetite
Researchers have discovered a drug that has been shown to selectively shrink excess fat by increasing fat cell metabolism...
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A2aAR protein holds clues for better drug design
Scientists have investigated a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases...
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Identification of hits and leads for human African trypanosomiasis
Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...
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Machine learning approaches as tools to accelerate drug discovery
Computational methods based on machine learning approaches are being introduced increasingly widely to screen the large number of molecules that have never participated in the drug discovery process, but which might have significant drug development potential. This article considers the latest advances in machine learning as applied to drug discovery...
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IONIS-HTTRx lowers deadly Huntington’s disease protein
The first drug targeting the cause of Huntington’s disease was safe and well-tolerated in its first human trial…
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Scientists discover a small molecule that halts kidney disease progression
A team of researchers set out to discover the disease pathways of a rare genetic kidney disease and found a compound that stops the disease in its tracks.
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Drug Target Review – Issue #4 2017
Issue 4 of Drug Target Review looks at artificial intelligence in drug discovery and features In-Depth Focuses on Screening, Hit to Lead and Informatics.
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Anle138b blocks toxic ion flow linked to Alzheimer’s disease
A new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease by stopping toxic ion flow in the brain...
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Inhibiting METTL3 destroys AML cells without harming normal blood cells
An unexpected drug target for acute myeloid leukaemia could open new avenues to develop effective treatments against the potentially lethal disease...
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CXCL5 protein found to stimulate tumour growth in prostate cancer
Researchers identify a pathway that causes tumour acceleration in metastatic prostate cancer cells...
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pIC found to prevent the development of liver cancer
A synthetic double-stranded RNA has potential for use as an anti-liver cancer vaccine...
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Declines in plasticity reveal promising targets for Alzheimer’s disease
Brain changes linked to memory loss may provide a new focus for exploring ways to treat or prevent dementia...
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Key psychiatric drug target comes into focus
Researchers have reported a major step forward towards designing more powerful psychiatric drugs with fewer side effects...
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CRISPR used to identify drug target for bowel cancer
CRISPR used to identify a new drug target for bowel cancer that is specific to tumour cells and therefore less toxic than conventional therapies...
