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Genes linked to cell survival during sepsis identified
Researchers have found a set of genes which helps cells survive during sepsis in mice and could inform potential treatments for the condition.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Promising drug developed for ovarian and pancreatic cancers
An antibody has been developed to block a protein secreted by the cells surrounding ovarian and pancreatic cancer tumours.
whitepaper
Whitepaper: CD4+ T-Cell Subsets
CD4+ T-cells play a central role in directing adaptive immune responses against invading microbial pathogens.
whitepaper
Whitepaper: Immune Cell Isolation & Culture
Immune cell isolation and culture are necessary for both basic research aimed at investigating the functions of different immune cell types, and for expanding specific immune cell populations for therapeutic purposes.
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Use of animal models decreases by 7 percent
In figures released by the Home Office, the use of animal models has decreased down to 3.52 million procedures in 2018.
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Cause of MS damage in the brain identified
A study has discovered that the damage of projection neurons in the brain is caused by immune cells, leading to MS.
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Study identifies protein key to successful chemotherapy
A protein has been discovered as key for effective chemotherapy, meaning improved treatments for chemotherapy resistance can be developed.
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Gene discovered to play key role in cancer metastasis
A study has identified a gene key in the spread of cancer, which could point to improving treatments for the condition, say the researchers.
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Macrophages identified as cause of endometriotic pain
Researchers have discovered that macrophages are a key cause for pain in women with endometriosis so could be a treatment target for the condition.
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Tauopathy-regulating protein identified
Researchers have discovered that the VPS35 molecule can be utilised in preventing neurodegenerative disorders.
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Role of protein in spread of cytomegalovirus discovered
A study has revealed the role of a protein which enables human cytomegalovirus to spread, the number one cause of congenital birth defects in the world.
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Inhibiting protein slows glioblastoma tumour growth
Researchers have discovered that inhibiting the ID1 protein slows the growth of glioblastoma tumours and reduces resistance to chemotherapy.
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New target identified for vestibular diseases
Researchers have discovered a potential treatment for vestibular conditions such as dizziness in animal models.
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Five latest developments for models
The use of models is a key feature of preclinical studies and in recent months there have been several new advancements in this area. This article investigates five of the latest developments.
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Synthetic molecules could provide new antibiotics
Using a novel technique, researchers have created new molecules effective at killing bacteria, providing new antibiotic drug targets.
