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Drug Discovery

 

In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.

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Analysing recombinant proteins by mass spectrometry

5 December 2015 | By , , ,

The drug discovery landscape is changing: no longer limited to big pharma, it is now within reach of academics and small consortia alike. Regardless of the setting, drug discovery requirements are always the same: strong biological theory, good chemical starting material and high quality protein samples from which to determine…

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Mass spectrometry and systems biology approaches in drug target discovery

5 December 2015 | By

Cells, organs and organisms are complex biological systems consisting of inter-related components that co-operatively work to maintain function and respond to change. Malfunction of any component can lead to pathologies and disease, leading to system-wide changes and subsequent adaptation. Hence, the ability to study and predict system behaviour will considerably…

ProteinSimple MFI 5000 Series
ProteinSimple MFI 5000 Series
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ProteinSimple MFI 5000 Series

4 December 2015 | By ProteinSimple

Address the US FDA requirement to characterize and quantify protein aggregates and other particle contaminants sized 1-70 microns in biotherapeutics...

DTR Issue 4 2015
DTR Issue 4 2015
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Drug Target Review – Issue #4 2015

3 December 2015 | By Drug Target Review

Included in this issue: Biomarkers, Mass Spectrometry, Target Validation, Drug Development, Personalised Medicines, Next-Generation Sequencing, Protein Expression, Companion Diagnostics, and much more...

Mass Spectrometry In-Depth Focus 2015
Mass Spectrometry In-Depth Focus 2015
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Mass Spectrometry In-Depth Focus 2015

3 December 2015 | By , , , ,

In this Mass Spectrometry In-Depth Focus: Michelle M. Hill from University of Queensland discusses Mass spectrometric and systems biology approaches in drug target discovery, and Nicola Burgess-Brown, Rod Chalk, Claire Strain-Damerell and Pravin Mahajan from the Structural Genomics Consortium look at analysing recombinant proteins by mass spectrometry...

The challenges associated with ‘de-risking’ earlystage therapeutic targets
The challenges associated with ‘de-risking’ earlystage therapeutic targets
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The challenges associated with ‘de-risking’ early-stage therapeutic targets

3 December 2015 | By , , ,

The pharmaceutical industry is searching for novel drug targets that could produce the next generation of ‘first-in-class’ therapeutic agents. The challenge for academia is to identify and translate such targets and to provide starting points and confidence in the underlying science. The aim should be to generate evidence that modulation…

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ProteinSimple NanoPro 1000

2 December 2015 | By ProteinSimple

Simple Western™ system for the characterization of post-translational protein modification by the detection of charge isoforms...

news

Heptares and Pfizer to focus on GPCR targets

30 November 2015 | By Victoria White

Heptares and Pfizer have announced they are to research and develop potential new medicines directed at up to 10 G protein-coupled receptor (GPCR) targets across multiple therapeutic areas...

news

Sleeping sickness project passes 20-month milestone

30 November 2015 | By Victoria White

The aim of the project is to design a drug to inhibit a key parasite enzyme involved in the conversion of blood sugars to energy, to be effective in small doses, even on advanced infections, and kill the parasite...