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Disease research

Scientists create “tracking” nanoagents to illuminate very small diseased tissues

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Scientists create “tracking” nanoagents to illuminate very small diseased tissues

9 November 2017 | By Drug Target Review

Polymer nanoagents that can ‘light up’ tiny areas of diseased tissues that conventional methods fail to detect, have been created by a research team led by NTU Singapore.

news

Selective PDE4D inhibitor shows potential to treat Fragile X syndrome

8 November 2017 | By Dr Zara Kassam (Drug Target Review)

Preclinical research suggests the potential utility of BPN14770, as a prospective treatment for Alzheimer's disease...

news

CXCR7 receptor reveals potential therapeutic target to reduce brain inflammation

6 November 2017 | By Dr Zara Kassam (Drug Target Review)

CXCR7 receptor identified as a potential therapeutic target for controlling multiple sclerosis, Parkinson's and AIDS...

news

Nano-sized gold particles, shaped to behave as clones in bio-medicine

3 November 2017 | By Dr Zara Kassam (Drug Target Review)

Gold nanoparticles have been shaped to improve their properties in biomedicine and photonics by using a special laser system...

news

Gut bacteria linked to age-related conditions

3 November 2017 | By Dr Zara Kassam (Drug Target Review)

Study suggests that chronic inflammation in the elderly -- thought to be involved in many age-related diseases -- is due to imbalances in gut bacteria...

news

NOX4 mechanism identified as a culprit in kidney cancer evolution

25 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified the molecular mechanism that causes kidney cancer to resist drug treatment...

news

Cryo-MOST approach maps whole-brain changes in Alzheimer’s disease

18 October 2017 | By Nic Losardo (Drug Target Review)

Micron-level, 3-D visualisation of protein deposits found in Alzheimer's disease could speed development of new treatments...

news

FRET imaging used to establish a beachhead at the NMDA receptor gate

10 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers use light-sensitive molecules to track proteins critical to cell signalling...

news

Underlying genetic causes of congenital heart disease identified

9 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have helped shed light on some of the underlying genetic causes of CHD as well as the long-term outlook for patients who carry these mutations...

news

DNA-based Zika vaccine found effective at inducing immune response

5 October 2017 | By Dr Zara Kassam (Drug Target Review)

A new generation DNA-based Zika vaccine is the first to demonstrate both safety and the ability to elicit an immune response against Zika in humans...

news

PET imaging used to track Zika virus infection

20 September 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have used PET imaging to study brain inflammation following Zika virus infection in mice, allowing investigators to study the progression of the disease over time...

news

NIH awards $15m to support development of 3-D human tissue models

13 September 2017 | By Dr Zara Kassam (Drug Target Review)

The NIH has announced 13 two-year awards totalling $15m, to develop 3-D microphysiological system platforms that model human disease...

news

Scientists characterise regulatory DNA sequences responsible for human diseases

25 August 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have developed an innovative system to identify and characterise the molecular components that control the activities of regulatory DNA sequences...

article

An overview of Alzheimer’s disease drug targets

17 February 2016 | By Maria Kuzikov (Fraunhofer-IME SP), Sheraz Gul (Fraunhofer-IME SP)

Alzheimer’s disease (AD) is the most common form of dementia which typically occurs after the age of 65 and is characterised by progressive cognitive impairment...

article

Finding a cure for neglected tropical diseases with cell-based assays

14 February 2016 | By David Shum (Institut Pasteur Korea)

Neglected tropical diseases pose a significant threat to public health and affect nearly one billion people in tropical and sub-tropical regions throughout the world. There is a pressing need to identify new therapeutics for NTDs and many developed nations are participating in drug discovery efforts...

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Disease research