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Disease research

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Main COVID-19 protease revealed, enabling screening of potential drugs

14 April 2020 | By Victoria Rees (Drug Target Review)

Chinese researchers who determined the crystal structure of the COVID-19 protease Mpro used this information to screen over 10,000 compounds to combat the coronavirus.

sagittal (side through view) magnetic resonance image of the brain with skull and supporting structures in purple and brain and brainstem in red and orange

article

Refreshing how we approach neuroscience with a novel screening technology

9 April 2020 | By Hannah Balfour (Drug Target Review)

Drug Target Review discusses how NETSseq, a novel profiling technology, is bringing new insights to neurodegenerative and psychiatric diseases.

artist impression of the anatomy of the lungs with bronchi and bronchioles highlighted in red

news

Human lung epithelium model being tested as a platform for COVID-19 research

9 April 2020 | By Hannah Balfour (Drug Target Review)

The developers of the lung epithelium model plan to investigate whether SARS-CoV-2 can infect and replicate in the model to assess whether it could be used in the fight against COVID-19.

Skull with faded blue outline with a pink brain inside with large red spot

news

Transplanted reprogrammed skin cells repair stroke-damaged rat brains

9 April 2020 | By Hannah Balfour (Drug Target Review)

Skin cells reprogrammed into nerves and transplanted into the stroke-damaged rat brains formed functional connections that restored mobility and touch sensation.

news

Scientists identify fusion peptide as promising COVID-19 drug target

8 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers working on related coronaviruses SARS and MERS have identified the membrane fusion peptide on the Spike protein as a possible drug target for SARS-CoV-2, the virus causing COVID-19.

pink coronavirus particles with purple spike proteins sticking off on a lilac background

news

MERS vaccine candidate could hold promise for COVID-19 vaccine

8 April 2020 | By Hannah Balfour (Drug Target Review)

The vaccine candidate protected all murine models from a lethal MERS infection and could also be effective against the SARS-CoV-2 virus causing COVID-19.

news

Receptors enabling COVID-19 infection found on cilia progenitor cells, study shows

8 April 2020 | By Victoria Rees (Drug Target Review)

Sequencing almost 60,000 cells, researchers have found that certain cilia progenitor cells have gene transcripts for ACE2 and co-factor TMPRSS2, enabling COVID-19 infection.

video

Video: Increased reproducibility with KingFisher™ instruments

8 April 2020 | By Thermo Fisher Scientific

ESHG 2019 Conference Presentation: Using KingFisher™ to increase reproducibility in new applications using challenging samples.

news

Researchers reveal how SARS antibody binds to COVID-19 coronavirus

7 April 2020 | By Victoria Rees (Drug Target Review)

The interaction between a SARS antibody called CR3022 and the COVID-19 coronavirus has been mapped by researchers, revealing a viral vulnerability.

news

Ursolic acid, compound in fruit peels, reverses damage in murine model of MS

7 April 2020 | By Hannah Balfour (Drug Target Review)

Ursolic acid was shown to halt the progression of chronic multiple sclerosis (MS) and reverse the damage already caused in a mouse model of the disease.

article

Predicting which diabetes treatments will reach clinical trials

7 April 2020 | By Victoria Rees (Drug Target Review)

Researchers at MIT have developed a mathematical model that can calculate whether diabetes treatments in pre-clinical trials will be successful in humans.

news

Ivermectin shows activity against COVID-19 in cell cultures

6 April 2020 | By Hannah Balfour (Drug Target Review)

A study has demonstrated that the anti-parasitic drug ivermectin may be effective against SARS-CoV-2, the virus which causes COVID-19.

news

Organoids for the development of drugs and diagnostics for NASH

3 April 2020 | By Hannah Balfour (Drug Target Review)

Organoids at different stages of non-alcoholic steatohepatitis (NASH) progression have been created to help in drug design and identification of diagnostic biomarkers.

news

Experimental mouse model of Duchenne muscular dystrophy developed

2 April 2020 | By Victoria Rees (Drug Target Review)

Researchers have created an accurate mouse model of Duchenne muscular dystrophy (DMD), showing that TGFβ is a potential target for the condition.

cartoon image of a brain with a large red ball inside representing a tumour

news

ABCC4 transporter could be a novel target for paediatric medulloblastoma treatments

2 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers demonstrated that ABCC4 is essential to signalling in the SHH subgroup of medulloblastomas and when expression was reduced in mice, the tumours shrank.

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Disease research