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Cell-based assays

news

Flaw found in lab models used to study human blood-brain barrier

8 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have uncovered a flaw in lab models used to study the human blood-brain barrier and a potential strategy to correct the error.

news

Researchers identify how Zika infects foetuses and a potential drug to prevent it

4 February 2021 | By Hannah Balfour (Drug Target Review)

According to scientists, maternal cells act as a reservoir for Zika, enabling the virus to pass from mother to foetus during pregnancy.

Coronavirus particle being injected by a syringe labelled 'Covid-19 Vaccine'

news

COVID-19 vaccine candidate stimulates neutralising antibody production in vivo

3 February 2021 | By Hannah Balfour (Drug Target Review)

The novel haptenised SARS-CoV-2 s-Spike vaccine, BVX-0320, stimulated mice to create neutralising antibodies that were able to reduce SARS-CoV-2 plaques in a neutralisation test.

news

Thapsigargin could be used as antiviral to treat COVID-19, study shows

3 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have discovered that thapsigargin has novel antiviral properties and is effective against COVID-19 in pre-clinical studies.

Computer screen displaying DNA strand, human body and organs and various tablets - idea of technology for medicine screening

news

Novel AI tool takes a DeepCE dive into potential drugs for COVID-19

2 February 2021 | By Hannah Balfour (Drug Target Review)

A new phenotype-based compound screening technology, called DeepCE, identified 10 compounds that could be repurposed for COVID-19.

news

Targeting the HCF-1 protein causes cancerous cells to self-destruct

1 February 2021 | By Hannah Balfour (Drug Target Review)

Disrupting the interaction between the MYC oncogene and its co-factor, host cell factor (HCF)–1, was sufficient to cause Burkitt’s lymphoma cells to self-destruct in vivo.

Coronavirus particles in green with purple extracellular proteins

news

N439K variant of SARS-CoV-2 is resistant to some neutralising antibodies, shows study

1 February 2021 | By Hannah Balfour (Drug Target Review)

The N439K mutation improves the interaction between SARS-CoV-2 Spike protein and the viral receptor ACE2 and eludes antibody-mediated immunity, say investigators.

SARS-CoV-2 spike protein bound to an ACE2 receptor on the cell surface

news

Heparin inhibits SARS-CoV-2 invasion, finds study

29 January 2021 | By Hannah Balfour (Drug Target Review)

Research suggests heparin could be repurposed for COVID-19 because it can bind to the SARS-CoV-2 Spike protein and prevent the virus from infecting cells in vitro.

webinar

Novel small molecule inhibitors of oncogenic SHP2 variants characterised by cellular target engagement

28 January 2021 | By Eurofins DiscoverX & Sanford Burnham Prebys Discovery

In this on-demand webinar industry experts discuss how the InCELL Pulse technology provides a valuable tool for the discovery and characterisation of novel SHP2 inhibitors.

news

In vitro model could aid the development of fatty liver disease treatments

26 January 2021 | By Hannah Balfour (Drug Target Review)

The patient-derived model of non-alcoholic fatty liver disease (NAFLD) accurately reproduced the complex human metabolic pathways involved in the development of the disease.

Real fluorescence microscopic view of human fibroblasts in culture. Nucleus are in blue, actin filaments are in pink, tubulin was labelled with green.

article

AI advancing drug discovery: the future is multi-cellular studies

26 January 2021 | By Hannah Balfour (Drug Target Review)

Drs Sam Cooper and Michael Briskin of Phenomic AI, discuss how artificial intelligence (AI) is enabling them to target multi-cellular interactions, such as those in the tumour stroma, for drug development.

news

Researchers uncover insights into pioneer transcription factors

25 January 2021 | By Victoria Rees (Drug Target Review)

A research team has discovered how proteins called pioneer transcription factors turn on vital genes in cells.

Close up of a light microscopy being used by a researcher - image shows just the metal lens and table with slide on

article

What is new in the world of imaging?

21 January 2021 | By Hannah Balfour (Drug Target Review)

In this article, Drug Target Review’s Hannah Balfour discusses three of the latest developments in imaging for disease research and drug development.

blue torso of a woman with a breast cancer tumour highlighted in glowing red

news

Activating androgen signalling has potent anti-breast cancer effects

19 January 2021 | By Hannah Balfour (Drug Target Review)

Researchers show selectively activating androgen receptors could be an effective treatment for oestrogen receptor positive breast cancers.

news

Novel nanobody combinations protect cells from SARS-CoV-2 in vitro

14 January 2021 | By Hannah Balfour (Drug Target Review)

By combining nanobodies targeting different regions of the SARS-CoV-2 Spike protein, researchers were able to protect cells from infection.

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Cell-based assays