webinar
New strategy to identify small molecule therapies
1 December 2016 | By Charles River
This webinar details a successful new strategy to identify small molecule therapies to treat protein-destabilizing monogenic disorders...
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Assays
An assay is an analytical procedure in laboratory medicine, pharmacology and molecular biology for measuring the activity of a target entity.
whitepaper
Whitepaper: KINOMEscan® ELECT Kinase screening and profiling services
Support your kinase inhibitor drug discovery programs with the most comprehensive kinase assay menu from DiscoverX’s KINOMEscan screening and profiling services, now with the fastest available turnaround time of 5 days for the ELECT services*...
product
DiscoverX In Vitro Pharmacology Services – Simplify Your Drug Discovery Workflow
21 October 2016 | By DiscoverX Corporation
Monitoring cellular drug penetration and drug-target interaction enables assessment of compound efficacy and confirmation of mode of action...
whitepaper
Guide: Protein-protein interaction assay now made easy with this complete user’s guide
This new guide reviewing the material and methods with HTRF® Toolbox reagents is for you...
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Cisbio Bioassays Toolbox products and services
4 October 2016 | By Cisbio
A comprehensive line of ready-to-use HTRF toolbox reagents labeled with HTRF fluorescent dyes for studying molecular interactions using time-resolved fluorescence energy transfer...
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Cisbio Bioassays EPIgeneous™ biochemical and cellular assays
4 October 2016 | By Cisbio
Rapid advancements have been made in understanding the key role epigenetic modifications play in regulating cell activity and their implications on cell health and disease progression...
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Cisbio Bioassays Cell signaling phospho-assays
4 October 2016 | By Cisbio
HTRF® cellular phospho-/total protein assays provide precise, sensitive measurement of endogeneous levels of phosphorylated and non phophorylated proteins able to be achieved in an endogenous cellular environment...
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Cisbio Bioassays GPCR – Kits and reagents to address the whole GPCR activation pathway
3 October 2016 | By Cisbio Bioassays
Cisbio Bioassays has supported GPCR investigation for many years regularly creating cutting edge assays and technologies suited to receptor characterization, compound screening and lead optimization...
whitepaper
Whitepaper: Development and Validation of Bio-Plex Pro™ Human Chemokine Assays
A new Bio-Plex Pro chemokine panel was validated for quantifying 40 human chemokines in one sample offering a significant advantage to researchers...
news
Envigo invests in non-animal assays, research and development
27 September 2016 | By Niamh Louise Marriott, Digital Content Producer
One example is the development of in vitro assays to enable the testing of 100 or so compounds per month for potential endocrine disrupting effects...
news
FDA gives Roche 510k clearance for Treponema pallidum assay to aid syphilis diagnosis
27 September 2016 | By Niamh Louise Marriott, Digital Content Producer
The Treponema pallidum assay is intended as an aid in the diagnosis of syphilis infection. The Roche Syphilis treponemal antibody test offers several...
whitepaper
Whitepaper: Accelerating Gαq GPCR Drug Discovery with recognized and reliable tool
Cisbio Bioassays has developed a GPCR platform based on the company’s HTRF® technology to measure second messenger accumulation...
article
Under the microscope with Joseph Zock, IntelliCyt Corporation
20 September 2016 | By Drug Target Review
Drug Target Review talks to Joseph Zock, Senior Director of Product Management at IntelliCyt Corporation, to find out more about assay developments and future innovations in this area of drug discovery...
article
High-throughput calcium flux assays: luminescent versus fluorescent readout
In vitro high-throughput cellular target-based assays are commonly used for hit identification targeting G-protein coupled receptors (GPCR). Agonist and antagonist identification of GPCRs often relies on the screening of large collections of chemicals using miniaturised in vitro cell-based functional assays. In the panel of assays, calcium mobilisation measured by aequorin…
article
A picture is worth a thousand endpoints: high-content imaging in drug discovery
Over the past few years several factors in the drug discovery industry have come together to drive an increased interest and subsequent surge in the use of high-content imaging. These include the high costs of attrition in the clinic due to lack of efficacy; increased hurdles and rising costs to…
