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An assay is an analytical procedure in laboratory medicine, pharmacology and molecular biology for measuring the activity of a target entity.
High throughput screening (HTS) has become an integral and productive part of early-stage drug discovery, delivering hits that were the starting points for hit-to-lead programmes and resulting in a number of marketed drugs. HTS can be carried out in a number of formats, ranging from simple biochemical (target-based) to whole…
Flow cytometry is a laser-based technology – a powerful tool for drug discovery and the screening process and can be used in all settings, including research, clinical, pharmaceutical and biotechnology. The increasing capabilities of flow cytometers make their incorporation into drug development and screening optimal...
Monitoring cellular drug permeability and target engagement enables assessment of compound efficacy and confirmation of mode of action. InCELL Pulse target engagement assays provide the ability to confirm compound cell entry and target engagement while overcoming limitations of current target engagement assays...
Cell2Sphere is the first simple 3D tissue culture kit for labs interested in more accurate, scalable and dynamic experimental research.
With an increasing industry focus on antibody drugs, there is an ever greater need for functional bioassays that interrogate the various mechanisms of action (MOA) for the therapeutic antibody...
IDBS has launched the E-WorkBook Cloud, an enterprise, Cloud-based platform designed specifically to meet the future challenges of scientific and R&D data management.
12 January 2017 | By ProteinSimple
Single-Cell Western system capable of analysing protein expression in ~1,000 single-cells in parallel to unlock heterogeneity...
Two-dimensional monolayer cell proliferation assays for cancer drug discovery have enabled large-scale screens. But they represent a simplified view of oncogenes or tumour suppressor genes as the genetic drivers of cancer cell proliferation.
21 December 2016 | By DiscoverX Corporations
Optimized Assays for a Multitude of GPCR Applications...
21 December 2016 | By DiscoverX Corporation
Designed for lead optimisation and safety profiling, DiscoverX’s SAFETYscan in vitro pharmacological profiling services improve off-target liability testing...
21 December 2016 | By DiscoverX Corporation
The movement of proteins between cellular compartments is essential for their specific biological role and the function of the cell...
In this Screening In-Depth Focus, scientists from the Assay Development and Screening Platform of Helmholtz Zentrum München provide an overview of different high-throughput screening (HTS)-applicable assay types that can be applied to drug discovery campaigns. Plus an interview with Lee Babiss, CEO of drug discovery firm X-Rx, on the benefits…
This application note describes a method to measure the ORAC of different food and beverage samples with a fluorometric assay...
The covalent modification of proteins by the attachment of ubiquitin (ubiquitination) is best known for its function to label proteins for proteasomal degradation. However, ubiquitination also plays non-proteasomal roles during signal transduction, DNA repair and protein sorting...
