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Therapeutics

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Three new assays to test COVID-19 antivirals developed

30 April 2020 | By Victoria Rees (Drug Target Review)

A series of three new assays to screen for drug compounds or proteins that combat the COVID-19 coronavirus has been developed.

news

Antibodies developed from llama show promise in fighting COVID-19

30 April 2020 | By Victoria Rees (Drug Target Review)

Engineering antibodies found in a llama, researchers have developed a potential COVID-19 therapy which they say can neutralise SARS-CoV-2.

article

Developing respiratory therapeutics for prophylaxis and treatment

30 April 2020 | By Hannah Balfour (Drug Target Review)

Drug Target Review explores antiviral Fc-conjugates and how they could be used as a COVID-19 prophylactic and therapeutic with Dr Jeff Stein, Cidara’s President and CEO.

news

AI platform developed to rapidly identify treatment regimens for infections, including COVID-19

29 April 2020 | By Victoria Rees (Drug Target Review)

A new AI tool has been created by researchers to identify the best treatment courses and doses for bacterial or viral infections, such as COVID-19.

COVID-19 - nanoparticles as drug delivery

news

Multidrug nanoparticles developed for treatment of COVID-19 inflammation

28 April 2020 | By Victoria Rees (Drug Target Review)

Multidrug nanoparticles for the targeted delivery of drugs could be used to combat inflammation in COVID-19 patients, say researchers.

hand holding a blood sample labelled 'covid-19' and a DNA strand, all in a grey-blue colour

news

NIAID releases strategic plan, outlining COVID-19 research priorities

28 April 2020 | By Hannah Balfour (Drug Target Review)

The US National Institute of Allergy and Infectious Diseases (NIAID) plan outlines four research priorities, including furthering understanding of SARS-CoV-2 viral transmission and pathogenesis and development of animal models.

article

Cytokine storms: a major killer in patients with severe COVID-19 infection

27 April 2020 | By Professor Saad Shakir (Drug Safety Research Unit)

Professor Saad Shakir explains why cytokine storms occur in COVID-19 patients and suggests potential therapies for the symptoms of the coronavirus.

article

Natural peptides versus COVID-19

25 April 2020 | By Oleg Kit (Interregional Academy of Personnel Management), Yuriy Kit (National Academy of Science of Ukraine)

Peptides could serve as a potential platform for development of novel drugs for the treatment of the COVID-19 coronavirus.

scientists in personal protective equipment looking at samples labelled COVID-19 under a microscope

news

Fundamental molecular research underpins our ability to combat COVD-19, says article

23 April 2020 | By Hannah Balfour (Drug Target Review)

Ali Shilatifard’s article explains how investment in institutes performing molecular research is essential, as it is the foundation for all attempts to combat COVID-19 and other future pandemics.

news

Lead SARS-CoV-2 inhibitor compound identified by researchers to treat COVID-19

23 April 2020 | By Victoria Rees (Drug Target Review)

Researchers have found a lead compound which they say inhibits SARS-CoV-2 viral replication and demonstrates good pharmacokinetic activity in vivo.

purple papillomavirus particles on a pink 'tissue'-like background

news

Glycomimetics could prevent COVID-19 from infecting human cells

21 April 2020 | By Hannah Balfour (Drug Target Review)

Glycomimetics, a novel class of antivirals, prevented influenza, herpes viruses and papillomaviruses from infecting cells in animal models and could show similar efficacy against COVID-19.

news

UK government funds 21 new research projects into COVID-19

20 April 2020 | By Victoria Rees (Drug Target Review)

A total of 21 COVID-19 research projects have been granted funding by the UK government, including vaccine and therapeutic development.

head and shoulders photo of an adult cynomolgus macaque

news

Cynomolgus macaques: a promising animal model of COVID-19 infection?

17 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers comparing the effects of SARS-CoV-2, SARS-CoV and MERS-CoV in cynomolgus macaques suggest they could be an effective animal model for testing COVID-19 therapeutics.

tablets, capsules and a laboratory scientist in a white coat on a swirling blue background

news

Screening 10,000 compounds identifies six potential COVID-19 therapeutics

17 April 2020 | By Hannah Balfour (Drug Target Review)

High-throughput screening of thousands of compounds has revealed several candidates, including lead compound ebselen, with the potential for treating COVID-19.

news

Specialised proteins could halt cytokine storms in COVID-19 patients

17 April 2020 | By Victoria Rees (Drug Target Review)

Researchers who developed modified proteins say this could be used in the fight against COVID-19, by tackling cytokine storms.

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Therapeutics