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Sheraz Gul

 

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Screening and beyond in drug discovery

Progressing drug discovery projects to a stage that attracts commercial…

14 June 2019 | By

Progressing drug discovery projects to a stage that attracts commercial interest is a challenging endeavour, evidenced by the fact that only a small proportion of drug discovery projects are successfully progressed to such a stage. A major cause of this is the lack of comprehensive profiling of compounds prior to…

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Assays In-Depth Focus 2019

In this In-Depth Focus: the importance of characterising chemical starting…

14 March 2019 | By

In this In-Depth Focus: the importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays, and why do we have no effective treatments for osteoarthritis?

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Lab Automation In-Depth Focus 2018

In this issue: how lab automation has accelerated pharmaceutical research…

16 March 2018 | By

In this issue: how lab automation has accelerated pharmaceutical research by simplifying operations, reducing manual tasks and increasing the efficiency, quality and reproducibility of results.

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Identification of hits and leads for human African trypanosomiasis

Neglected tropical diseases (NTD) affect more than one billion people…

13 December 2017 | By , ,

Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...

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Informatics In-Depth Focus 2017

In this In-Depth Focus we look at using bioinformatics sequence…

8 December 2017 | By

In this In-Depth Focus we look at using bioinformatics sequence similarities to optimise repurposing activities; informatics infrastructure in neglected disease research, and machine learning for accelerating drug discovery.

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Hit To Lead In-Depth Focus 2017

In this In-Depth Focus we look at a pragmatic approach…

6 December 2017 | By

In this In-Depth Focus we look at a pragmatic approach to hit validation following biochemical high-throughput screening as well as identification of hits and leads for human African trypanosomiasis.

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Structure based drug discovery facilitated by crystallography

Drugs exert therapeutically meaningful effects if they bind with appropriate…

15 September 2017 | By ,

Drugs exert therapeutically meaningful effects if they bind with appropriate selectively and potency to their respective targets. Although many of the assay techniques employed in early-stage drug discovery provide evidence that a drug is acting upon the target under investigation, this is often indirect and the site of action and…

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Assays In-Depth Focus 2017

This in-depth focus looks at improving assay techniques to produce…

8 September 2017 | By

This in-depth focus looks at improving assay techniques to produce more detailed results using crystallography. It also covers some aspects of high-content screening assay development that are critical to successful implementation...

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Drug Target Review – Issue #3 2017

Included in this issue: The importance of industry partnerships; Calcilytics…

6 September 2017 | By

Included in this issue: The importance of industry partnerships; Calcilytics as potential novel therapeutic treatments to halt Alzheimer's disease; Accelerating neuroscience research with flow cytometry...

reference

Fearnhead H, Gul S. Using clinical drug resistance to kill cancer cells. Drug Target Review. 2017;3:12-14

References Pal C, Papp B, Lazar V. Collateral sensitivity of…

12 July 2017 | By

References Pal C, Papp B, Lazar V. Collateral sensitivity of antibiotic-resistant microbes. Trends Microbiol. 2015;23:401-7. Guthrie R, Loebeck ME, Hillman MJ, Zgorzynski F. Tests for collateral sensitivity or cross resistance in bacterial mutants resistant to amethopterin or purine analogs. Cancer Res. 1958;18:319-34. Imamovic L, Sommer MO. Use of collateral sensitivity…

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Screening In-Depth Focus 2017

Included in this Screening In-Depth Focus: Phenotypic and target-based screening;…

5 June 2017 | By

Included in this Screening In-Depth Focus: Phenotypic and target-based screening; Killing cancer cells using clinical drug resistance; Inflammatory biomarkers as a herbal anti-arthritic drug discovery tool...

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Under the microscope with Labcyte

Dr Sheraz Gul, Head of Assay Development and Screening at…

15 March 2017 | By

Dr Sheraz Gul, Head of Assay Development and Screening at the Fraunhofer Institute for Molecular Biology and Applied Ecology, answers questions on assay procedures...