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US National Institutes of Health (NIH)

Assessing compound activity to accelerate drug discovery

22 June 2021 | By Victoria Rees (Drug Target Review)

In this article, Drug Target Review’s Victoria Rees explores a new screening platform that assesses the biological activity of molecules to identify potential drugs. Using their new technique, researchers from the US National Institutes of Health (NIH) identified potential COVID-19 therapeutics.

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Two COVID-19 vaccines show safety and strong immunity in infant model

16 June 2021 | By Victoria Rees (Drug Target Review)

Two groups of infant rhesus macaques received one of two potential COVID-19 vaccines, which were shown to elicit high levels of neutralising antibodies.

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TEMPOL drug shows promise as antiviral treatment for COVID-19

8 June 2021 | By Victoria Rees (Drug Target Review)

The experimental drug TEMPOL has demonstrated antiviral activity against COVID-19 in a pre-clinical study in cell cultures.

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Airway-on-a-chip technology enables COVID-19 drug repurposing

7 May 2021 | By Victoria Rees (Drug Target Review)

An airway-on-a-chip has been used to show that amodiaquine inhibits SARS-CoV-2 infection, making it a potential COVID-19 therapeutic.

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Small-molecule cocktail could improve use of stem cells in treatments

4 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that Chroman 1, Emricasan and trans-ISRIB, in combination with polyamines, are effective at protecting induced pluripotent stem cells from stress.

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Stem cell therapy repairs damage from dementia in mouse brains

22 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a stem cell therapy that could treat the damage caused by dementia by launching a repair response.

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Team develops cerebral organoid system to screen for CJD drugs

20 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed their previously created brain organoid to test for potential drugs against Creutzfeldt-Jakob disease (CJD).

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MK-4482 antiviral effective against SARS-CoV-2 in hamster study

19 April 2021 | By Victoria Rees (Drug Target Review)

The drug MK-4482 decreased viral levels in the lungs of hamsters treated for SARS-CoV-2 infection, researchers have shown.

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Fighting HIV: could antibodies be the answer?

1 April 2021 | By Victoria Rees (Drug Target Review)

Although a cure for HIV continues to elude scientists, strategies to control the virus and immunise people are developing at rapid pace. Here, Drug Target Review’s Victoria Rees discusses why researchers are focusing on antibodies as approaches to combat HIV and highlights recent findings from two pre-clinical studies into how…

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CD8⁺ T cells recognise recent SARS-CoV-2 variants, scientists say

31 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have revealed that T cells in blood samples from people who recovered from COVID-19 responded to SARS-CoV-2 variants.

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Scientists find evidence that SARS-CoV-2 infects cells in mouth

26 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that SARS-CoV-2 infects mouth cells, which could inform the development of treatments against the oral symptoms of COVID-19.

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Mosquito protein could hold key to therapeutics against flaviviruses

11 March 2021 | By Victoria Rees (Drug Target Review)

A study has shown the mosquito protein AEG12 inhibits flaviviruses, the family of viruses that cause yellow fever, dengue and Zika.

Graphic of a person breathing in a stream of SARS-CoV-2 viral particles, some going down the throat to the lungs, others going up to the brain - idea of neurological symptoms of COVID-19

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New database to track neurological symptoms of COVID-19

28 January 2021 | By Hannah Balfour (Drug Target Review)

NeuroCOVID will be a resource of clinical information and biospecimens from people who experience neurological problems associated with SARS-CoV-2 infection.

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Scientists identify nutrient that helps prevent bacterial infection

19 January 2021 | By Victoria Rees (Drug Target Review)

Scientists have identified a potential alternative to antibiotics, a nutrient named taurine that helps the microbiome kill invading bacteria.

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New DNA-editing technique extends lifespan of mice with progeria

7 January 2021 | By Victoria Rees (Drug Target Review)

Researchers have used a novel DNA-editing method to convert one base pair to another, increasing the lifespan of mice with progeria.

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US National Institutes of Health (NIH)