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Possible method to apply CAR T-cell therapy to solid tumours developed
Researchers have developed a CAR T-cell engineering technique to ensure that only cancer cells are targeted, leaving healthy cells alone in solid tumours.
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University of Helsinki
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SARS-CoV-2 also uses neuropilin-1 to infect human cells
Researchers reveal that SARS-CoV-2 is more infectious than SARS-CoV because it can use both ACE2 and neuropilin-1 to infect cells.
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BT13 molecule shows promise for halting Parkinson’s
A molecule has been shown to increase dopamine levels in the brains of mice, offering hope for stopping the progression of Parkinson’s.
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Mutated blood stem cell receptors could be therapeutic targets for leukaemia
Researchers have identified that in leukaemia, mutated receptors allow blood stem cells to activate one another without the proper signal and suggest this discovery could lead to targeted novel therapies.
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Researchers identify potential enterovirus drug target
A study has discovered a pathway that allows the enterovirus to successfully infect cells and promote genome release which could be a therapeutic target.
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Study reveals vulnerability of common pathogenic viruses
Researchers have developed a stabilisation technique for widespread viruses, creating drug opportunity.
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Scientists developed a new mouse model of Hirschsprung’s disease
Researchers have developed the first viable mouse model of Hirschsprung’s disease and associated enterocolitis with a defect in GDNF/GFRa1/RET signalling...
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Antibacterial compounds focusing on LsrK kinase
Researchers at the University of Eastern Finland have developed antibacterial compounds based on the action of LsrK kinase...
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Researchers develop a potential tool for efficacious targeted cancer therapy
Researchers have developed PeptiENV, a cancer vaccine platform, which can be used to improve the therapeutic efficacy of oncolytic enveloped viruses...
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CRISPRa used to reprogramme skin cells into pluripotent stem cells
Researchers have now for the first time succeeded in converting skin cells into pluripotent stem cells by activating the cell's own genes...
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CRISPR-Cas9 tool could increase cancer risk
Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer...
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Migraine study provides insight into the disease
By studying migraine patients researchers have identified over 40 significant genetic risk variants that predispose individuals to migraines...
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Lymphatic endothelial cells are found to promote the spread of melanoma
Scientists have investigated the mechanisms by which the lymphatic endothelial cells modulate metastasis in melanoma, providing new targets for therapy development.
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New gene mutations found in white blood cells in rheumatoid arthritis patients
Finnish researchers have found that an accumulation of gene mutations, similar to those typically seen in the development of cancer, also occur in some patients with rheumatoid arthritis.
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Premature cell differentiation leads to disorders in pancreatic development
Neonatal diabetes mellitus (NDM), or diabetes among infants less than six months of age, is a rare form of diabetes caused by a mutation in genes crusial to the development or function of beta cells. In about half of such cases, the disease becomes permanent (PNDM). Mutations in more than…
