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Possible method to apply CAR T-cell therapy to solid tumours developed

19 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a CAR T-cell engineering technique to ensure that only cancer cells are targeted, leaving healthy cells alone in solid tumours.

SARS-CoV-2 particles entering human cells

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SARS-CoV-2 also uses neuropilin-1 to infect human cells

21 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers reveal that SARS-CoV-2 is more infectious than SARS-CoV because it can use both ACE2 and neuropilin-1 to infect cells.

Parkinson's Disease dopamine neuron with alpha-synuclein Lewy Body inside

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BT13 molecule shows promise for halting Parkinson’s

18 February 2020 | By Nikki Withers (Drug Target Review)

A molecule has been shown to increase dopamine levels in the brains of mice, offering hope for stopping the progression of Parkinson’s.

blood vessel with few red blood cells and many white blood cells, indicating leukaemia

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Mutated blood stem cell receptors could be therapeutic targets for leukaemia

7 February 2020 | By Hannah Balfour (Drug Target Review)

Researchers have identified that in leukaemia, mutated receptors allow blood stem cells to activate one another without the proper signal and suggest this discovery could lead to targeted novel therapies.

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Researchers identify potential enterovirus drug target

19 August 2019 | By Victoria Rees (Drug Target Review)

A study has discovered a pathway that allows the enterovirus to successfully infect cells and promote genome release which could be a therapeutic target.

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Study reveals vulnerability of common pathogenic viruses

13 June 2019 | By Victoria Rees (Drug Target Review)

Researchers have developed a stabilisation technique for widespread viruses, creating drug opportunity.

news

Scientists developed a new mouse model of Hirschsprung’s disease

17 January 2019 | By Drug Target Review

Researchers have developed the first viable mouse model of Hirschsprung’s disease and associated enterocolitis with a defect in GDNF/GFRa1/RET signalling...

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Antibacterial compounds focusing on LsrK kinase

1 November 2018 | By Drug Target Review

Researchers at the University of Eastern Finland have developed antibacterial compounds based on the action of LsrK kinase...

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Researchers develop a potential tool for efficacious targeted cancer therapy

8 October 2018 | By Drug Target Review

Researchers have developed PeptiENV, a cancer vaccine platform, which can be used to improve the therapeutic efficacy of oncolytic enveloped viruses...

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CRISPRa used to reprogramme skin cells into pluripotent stem cells

6 July 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have now for the first time succeeded in converting skin cells into pluripotent stem cells by activating the cell's own genes...

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CRISPR-Cas9 tool could increase cancer risk

12 June 2018 | By Dr Zara Kassam (Drug Target Review)

Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer...

news

Migraine study provides insight into the disease

8 May 2018 | By Drug Target Review

By studying migraine patients researchers have identified over 40 significant genetic risk variants that predispose individuals to migraines...

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Lymphatic endothelial cells are found to promote the spread of melanoma

4 May 2018 | By Drug Target Review

Scientists have investigated the mechanisms by which the lymphatic endothelial cells modulate metastasis in melanoma, providing new targets for therapy development.

New gene mutations found in white blood cells in rheumatoid arthritis patients

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New gene mutations found in white blood cells in rheumatoid arthritis patients

27 June 2017 | By Sarah Wills (Drug Target Review)

Finnish researchers have found that an accumulation of gene mutations, similar to those typically seen in the development of cancer, also occur in some patients with rheumatoid arthritis.

news

Premature cell differentiation leads to disorders in pancreatic development

12 April 2017 | By Niamh Marriott (Drug Target Review)

Neonatal diabetes mellitus (NDM), or diabetes among infants less than six months of age, is a rare form of diabetes caused by a mutation in genes crusial to the development or function of beta cells. In about half of such cases, the disease becomes permanent (PNDM). Mutations in more than…

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