Approved MS medication inhibits SARS-CoV-2 replication in vitro
Dimethyl fumarate (DMF), a multiple sclerosis (MS) drug, inhibited SARS-CoV-2 replication and the hyper-inflammatory immune response associated with COVID-19.
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SARS antiviral nitric oxide could be used to treat SARS-CoV-2
The nitric oxide treatment used during the 2003 SARS epidemic could be used as an antiviral against SARS-CoV-2, researchers say.
![Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].](https://drug.russellpublishing.co.uk/wp-content/uploads/ovarian-cancer-spheroid-3D-model-750x500.jpg)
![Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].](https://drug.russellpublishing.co.uk/wp-content/uploads/ovarian-cancer-spheroid-3D-model-e1601896830935.jpg)
Novel tumour spheroids could improve ovarian cancer treatments
Researchers have developed a new self-assembling three-dimensional (3D) ovarian cancer tumour model to recreate the in vitro disease more accurately.
Hit-to-lead from small molecule library screens can identify new vaccine adjuvants
Researchers have screened small molecule libraries and then applied hit-to-lead approaches to discover effective vaccine adjuvants.
Team identifies T-cell epitopes to inform COVID-19 vaccine development
Researchers studied 180 convalescent COVID-19 patients to reveal T-cell epitopes that they say can be targeted by a vaccine.
Malaria compounds found to kill Cryptosporidium parasite
Researchers have shown that bicyclic azetidines, medicines used to treat malaria, can also kill the Cryptosporidium parasite in mice.
Epigenetic marks could be the target of future Alzheimer’s therapies
New findings suggest that late-onset Alzheimer's Disease (AD) is driven by epigenetic changes in the brain.
The NF-κB pathway drives fatal inflammation in COVID-19, say scientists
Researchers found that the SARS-CoV-2 infection activates the NF-κB pathway, driving unchecked inflammation that contributes to total organ failure in COVID-19 patients.
![Glioblastoma Multiforme (GBM) cells in culture [Credit: Dr Jin-Min Nam].](https://drug.russellpublishing.co.uk/wp-content/uploads/glioblastoma-cells-750x500.jpg)
![Glioblastoma Multiforme (GBM) cells in culture [Credit: Dr Jin-Min Nam].](https://drug.russellpublishing.co.uk/wp-content/uploads/glioblastoma-cells-e1601552379990.jpg)
Identifying radioresistance drivers in glioblastoma multiforme
According to researchers, Rab27b and epiregulin contribute to the development of radioresistance and could be targeted to improve glioblastoma patient survival.
New thermofluidic technology allows researchers to bioprint cells in 3D
Researchers have used heat to develop a new way to bioengineer cells that grow a certain way and bioprint 3D tissues.
Novel RNA-targeting molecule can halt SARS-CoV-2 replication
The C5 compound targets the frameshifting element that allows SARS-CoV-2 to effectively replicate and marks the genome for destruction to stop the infection spreading.
Researchers identify mutations in single genes that lead to cerebral palsy
A new study has shown that the mutated FBXO31 and RHOB genes can each alone cause cerebral palsy, offering potential drug targets.
Using CRISPR to develop a cutaneous leishmaniasis vaccine
Researchers used CRISPR gene-editing to develop a vaccine able to protect against the spread of the Leishmania major parasite which causes cutaneous leishmaniasis.
Researchers map pathoconnectome of eye disease and retinal circuitry
Scientists have produced the first pathoconnectome - an open access map for other researchers that shows how eye disease can alter retinal circuitry.
Study reveals 10 SARS-CoV-2 epitopes that could be targeted by antibodies
An analysis of SARS-CoV-2 has allowed researchers to identify epitopes recognised by a large fraction of COVID-19 patients, with 10 that could be targeted by antibodies.
