Promising preclinical drug candidate suppresses HIV 9 January 2018 | By Dr Zara Kassam (Drug Target Review) A team of researchers have tested a chemical compound that suppresses HIV, protects immune cells, and remains effective for weeks with a single dose...
X chromosome reactivation could treat Rett syndrome 8 January 2018 | By Dr Zara Kassam (Drug Target Review) Reactivation of the inactive X chromosome could lead to an increased expression of the healthy protein underlying the neurodevelopmental disorder...
Near-infrared molecular imaging identifies lung nodules for resection in osteosarcoma 8 January 2018 | By Dr Zara Kassam (Drug Target Review) In a proof-of-principle case report, researchers announce that targeted fluorescence successfully identified pulmonary metastases in a patient with osteosarcoma...
Precision editing of gut bacteria used to treat colitis 8 January 2018 | By Dr Zara Kassam (Drug Target Review) Researchers have used precision editing of the bacterial populations in the gut to prevent or reduce the severity of inflammation in a mouse model of colitis...
Anti-obesity drug shrinks fat without suppressing appetite 5 January 2018 | By Dr Zara Kassam (Drug Target Review) Researchers have discovered a drug that has been shown to selectively shrink excess fat by increasing fat cell metabolism...
Brainstem changes identified in Parkinson’s disease 5 January 2018 | By Dr Zara Kassam (Drug Target Review) Researchers have found that patients with Parkinson's disease have more errors in the mitochondrial DNA within the brainstem, leading to increased cell death...
CXCR4 receptor provides therapeutic target for ovarian cancer 5 January 2018 | By Dr Zara Kassam (Drug Target Review) Researchers have described a key cellular receptor in the processes of metastasis in ovarian cancer, the findings may lead to the use of CXCR4 inhibitors as a therapeutic target...
Epigenetic compound inhibits the growth of melanoma cells 4 January 2018 | By Dr Zara Kassam (Drug Target Review) Researchers have developed a compound that successfully inhibits the growth of melanoma cells by targeting specific epigenetic modifying proteins...
Thorase protein may be linked to schizophrenia 4 January 2018 | By Dr Zara Kassam (Drug Target Review) Epilepsy drug reverses anti-social behaviours in mice with genes that produce variant proteins...
Cellular barcoding helps scientists understand the behaviour of stem cells 4 January 2018 | By Dr Zara Kassam (Drug Target Review) Use of labelling technology in mice leads to discoveries in process of natural blood formation...
Bacterial cells designed to reflect sound waves for ultrasound imaging 3 January 2018 | By Dr Zara Kassam (Drug Target Review) New technology may one day allow doctors to image therapeutic bacterial cells in patients...
Nano-medicine inhibits progression of pancreatic cancer 3 January 2018 | By Dr Zara Kassam (Drug Target Review) Survival rates in pancreatic cancer linked to the inverse correlation between specific oncogene and tumour suppressant microRNA...
Stem cell therapy discovery for age-related macular degeneration 3 January 2018 | By Dr Zara Kassam (Drug Target Review) Stem cell-derived retinal cells need primary cilia to support the survival of light-sensing photoreceptors...
Organ-on-a-chip device successfully models heart disease 2 January 2018 | By Dr Zara Kassam (Drug Target Review) A new device that models atherosclerosis can help researchers better understand the disease, develop therapies and diagnose blood health...
A2aAR protein holds clues for better drug design 2 January 2018 | By Dr Zara Kassam (Drug Target Review) Scientists have investigated a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases...
