Promising preclinical drug candidate suppresses HIV
A team of researchers have tested a chemical compound that suppresses HIV, protects immune cells, and remains effective for weeks with a single dose...
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X chromosome reactivation could treat Rett syndrome
Reactivation of the inactive X chromosome could lead to an increased expression of the healthy protein underlying the neurodevelopmental disorder...
Near-infrared molecular imaging identifies lung nodules for resection in osteosarcoma
In a proof-of-principle case report, researchers announce that targeted fluorescence successfully identified pulmonary metastases in a patient with osteosarcoma...
Precision editing of gut bacteria used to treat colitis
Researchers have used precision editing of the bacterial populations in the gut to prevent or reduce the severity of inflammation in a mouse model of colitis...
Anti-obesity drug shrinks fat without suppressing appetite
Researchers have discovered a drug that has been shown to selectively shrink excess fat by increasing fat cell metabolism...
Brainstem changes identified in Parkinson’s disease
Researchers have found that patients with Parkinson's disease have more errors in the mitochondrial DNA within the brainstem, leading to increased cell death...
CXCR4 receptor provides therapeutic target for ovarian cancer
Researchers have described a key cellular receptor in the processes of metastasis in ovarian cancer, the findings may lead to the use of CXCR4 inhibitors as a therapeutic target...
Epigenetic compound inhibits the growth of melanoma cells
Researchers have developed a compound that successfully inhibits the growth of melanoma cells by targeting specific epigenetic modifying proteins...
Thorase protein may be linked to schizophrenia
Epilepsy drug reverses anti-social behaviours in mice with genes that produce variant proteins...
Cellular barcoding helps scientists understand the behaviour of stem cells
Use of labelling technology in mice leads to discoveries in process of natural blood formation...
Bacterial cells designed to reflect sound waves for ultrasound imaging
New technology may one day allow doctors to image therapeutic bacterial cells in patients...
Nano-medicine inhibits progression of pancreatic cancer
Survival rates in pancreatic cancer linked to the inverse correlation between specific oncogene and tumour suppressant microRNA...
Stem cell therapy discovery for age-related macular degeneration
Stem cell-derived retinal cells need primary cilia to support the survival of light-sensing photoreceptors...
Organ-on-a-chip device successfully models heart disease
A new device that models atherosclerosis can help researchers better understand the disease, develop therapies and diagnose blood health...
A2aAR protein holds clues for better drug design
Scientists have investigated a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases...
