Ten genes revealed to contribute to development of schizophrenia 18 October 2019 | By Victoria Rees (Drug Target Review) Whole exome sequencing has been used by researchers to reveal 10 genes implicated in the development of schizophrenia.
Study finds astrocytes critical in progression of Huntington’s disease 18 October 2019 | By Victoria Rees (Drug Target Review) The new research shows that astrocytes contribute to Huntington’s disease symptoms, but suppressing a mutation stops the disease from progressing.
New drug shows promise as immune therapy for cancers 17 October 2019 | By Rachael Harper (Drug Target Review) A therapy has been developed which uses a synthetic RNA molecule developed to fight viruses to trigger an immune response against tumours in mice.
Full gene-replacement model developed for Alzheimer’s MAPT gene research 17 October 2019 | By Drug Target Review Researchers in the US have successfully produced a mouse model with a human MAPT gene to enable more accurate research into Alzheimer’s therapy.
Selective inhibitor could reduce resistance to cancer therapies 16 October 2019 | By Victoria Rees (Drug Target Review) A study has found a selective inhibitor for an enzyme that allows cancer cells to mutate and become resistant to treatments.
Platform may find new options for mental health treatment 16 October 2019 | By Rachael Harper (Drug Target Review) A drug discovery platform for mental health treatment could also help to identify mechanisms for the treatment of substance use disorders.
Method developed for quicker and simpler production of lipidated proteins 16 October 2019 | By Rachael Harper (Drug Target Review) A simple and direct method of introducing lipids into protein has been developed using palladium as a catalyst.
Mucus has been shown to tame microbes in new study 15 October 2019 | By Rachael Harper (Drug Target Review) Glycans, which are found in mucus, have the ability to regulate how microbes behave and could lead to new therapeutics.
Dementia spreads via connected brain networks, finds study 15 October 2019 | By Victoria Rees (Drug Target Review) New findings on dementia reveal that brain atrophy spreads via connected brain networks, rather than simply adjacent areas of the brain.
Researchers develop new immuno-oncology technique 15 October 2019 | By Victoria Rees (Drug Target Review) A team has used viral gene editing and CRISPR to form a system that marks tumours for destruction, potentially improving immunotherapies.
Cancer-suppressing cells identified in pancreatic cancer 14 October 2019 | By Rachael Harper (Drug Target Review) Cells containing Meflin play a role in restraining the progression of pancreatic cancer and could lead to new therapies against the disease.
Microglia critical for neurodegeneration in mice, study finds 14 October 2019 | By Victoria Rees (Drug Target Review) Microglia brain immune cells are vital in conjunction with the APOE4 gene during the development of Alzheimer’s in mouse models, researchers have found.
CRISPR RNA-cutting enzyme programmed to kill viruses in human cells 14 October 2019 | By Rachael Harper (Drug Target Review) Researchers have developed CRISPR-Cas13 enzyme-based technology that can be programmed to both detect and destroy RNA-based viruses in human cells.
‘Tricking’ bacteria could lead to more effective antibiotics 11 October 2019 | By Rachael Harper (Drug Target Review) A technique to 'trick' bacteria into revealing pores in their cell walls has been developed and targeting these could make antibiotics more effective.
3D tissue models of brain tumours created in brain-mimicking environment 11 October 2019 | By Rachael Harper (Drug Target Review) A new platform has the potential to better understand what dictates the invasive behaviour of brain tumours.
