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New generation of CAR T cells developed

6 December 2019 | By Hannah Balfour (Drug Target Review)

Researchers have reprogrammed CAR T cells to prevent them becoming exhausted after prolonged activity, presenting a possible new therapy for solid tumours.

New treatment possible to tackle drug-resistant strains of TB

5 December 2019 | By Rachael Harper (Drug Target Review)

A new discovery could lead to the development of a drug for untreatable strains of TB, which can target uptake of the very amino acid that enables the bacteria to spread within the body.

Cancer immunotherapies may be improved with early immune response

5 December 2019 | By Rachael Harper (Drug Target Review)

A new mechanism has been reported for detecting foreign material during early immune responses which may help detect elusive cancers.

Two new retinal pigment epithelial cell models developed

5 December 2019 | By Victoria Rees (Drug Target Review)

Researchers have created two new cellular models that can be used in the study of ocular diseases and drug testing.

Common signalling pathway across cancer and diabetes discovered by researchers

5 December 2019 | By Hannah Balfour (Drug Target Review)

Researchers have found that the TRAP-alpha insulin biosynthesis pathway is essential in both cancer and diabetes, with a common primordial ancestor discovered in C. elegans.

Medicine against bone disease found in Saussurea leaves

4 December 2019 | By Rachael Harper (Drug Target Review)

Isolated components found in the Saussurea controversa plant have antimicrobial and regenerative properties which could lead to a treatment for bone diseases.

New screening method identifies potential compounds to combat cancer

4 December 2019 | By Hannah Balfour (Drug Target Review)

The new screening technique may enable development of novel combination-immunotherapy regimens against cancers and persistent infections.

Study shows that CRISPR-Cas9 gene editing has a low risk of mistakes

4 December 2019 | By Rachael Harper (Drug Target Review)

A study has shown that unintended mutations from gene editing with CRISPR-Cas9 are rare in zebrafish, providing reassurance that this technology is a valid tool with great promise for the treatment of genetic disorders.

Sartolab^® MultiStation

4 December 2019 | By Sartorius

For a hands-free filtration of up to 6 x 50 mL samples in parallel.

Vasomotion revealed as potential strategy to treat Alzheimer’s

4 December 2019 | By Victoria Rees (Drug Target Review)

A study has demonstrated that inducing brain vessel pulsations helps to clear substances from the brains of mice, so could be used to stop amyloid-β build up in the development of Alzheimer’s.

Scientists discover how strep bacterium hides from the immune system

3 December 2019 | By Rachael Harper (Drug Target Review)

Produced by Group A Streptococcus, researchers have discovered the S protein, which binds to the red blood cell membrane to avoid being destroyed by immune cells and could be a target for anti-virulence drugs.

Therapeutic target found for diseases caused by lipid accumulation in cells

3 December 2019 | By Rachael Harper (Drug Target Review)

Researchers have identified the protein Annexin A6 as a potential therapeutical target against diseases that are caused by the accumulation of cholesterol and other lipids in endosomes.

cartoon pancreas with red 'tumour' highlighted

PJ34 triggers self-destruction of human pancreatic cancer cells

3 December 2019 | By Hannah Balfour (Drug Target Review)

A study conducted on human pancreatic tumours transplanted in mice reveals promise for an effective therapy in the future, say researchers.

Researchers must not rely on generic online searches for chemical probes, study finds

3 December 2019 | By Victoria Rees (Drug Target Review)

The ICR has revealed that during drug discovery, researchers should not use general search engines and vendor catalogue information to decide on their use of chemical probes.

Protein tag developed to aid in study of the immune system

2 December 2019 | By Rachael Harper (Drug Target Review)

A novel approach to better understand a basic defence mechanism of the immune system has been developed using the ISG15 protein which could lead to novel antimicrobial drugs.

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