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High throughput screening (HTS) has become an integral and productive part of early-stage drug discovery, delivering hits that were the starting points for hit-to-lead programmes and resulting in a number of marketed drugs. HTS can be carried out in a number of formats, ranging from simple biochemical (target-based) to whole…
20 February 2017 | By BMG Labtech GmbH
Due to their role in signal transmission from the outside to the inside of a cell, G-protein coupled receptors (GPCRs) are prominent drug targets.
Flow cytometry is a laser-based technology – a powerful tool for drug discovery and the screening process and can be used in all settings, including research, clinical, pharmaceutical and biotechnology. The increasing capabilities of flow cytometers make their incorporation into drug development and screening optimal...
Ligands are useful tools for studying how proteins work in cells and could lead to the development of new drugs.
Cell2Sphere is the first simple 3D tissue culture kit for labs interested in more accurate, scalable and dynamic experimental research.
The use of benzodiazepines and benzodiazepine-like drugs was associated with a 20% increased risk of stroke among persons with Alzheimer’s disease, shows a recent study from the University of Eastern Finland.
Information on significant properties of pharmaceutical tablets, such as their mechanical strength and dissolution, can now be obtained without resorting to the conventional, time-consuming and destructive testing methods, according to a new study completed at the University of Eastern Finland.
Two-dimensional monolayer cell proliferation assays for cancer drug discovery have enabled large-scale screens. But they represent a simplified view of oncogenes or tumour suppressor genes as the genetic drivers of cancer cell proliferation.
21 December 2016 | By DiscoverX Corporations
Optimized Assays for a Multitude of GPCR Applications...
21 December 2016 | By DiscoverX Corporation
Designed for lead optimisation and safety profiling, DiscoverX’s SAFETYscan in vitro pharmacological profiling services improve off-target liability testing...
21 December 2016 | By DiscoverX Corporation
Rapid Target Discovery, Validation, and Selectivity Determination...
Experts at EUCAST have found that genetic methods cannot yet be used to test for susceptibility in a number of important bacterial species.
In this Screening In-Depth Focus, scientists from the Assay Development and Screening Platform of Helmholtz Zentrum München provide an overview of different high-throughput screening (HTS)-applicable assay types that can be applied to drug discovery campaigns. Plus an interview with Lee Babiss, CEO of drug discovery firm X-Rx, on the benefits…
This application note describes a method to measure the ORAC of different food and beverage samples with a fluorometric assay...
