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Aortic plaques may contribute to liver disease progression
Aortic atherosclerotic plaque inflammation may contribute to the progression of non-alcoholic fatty liver disease to liver fibrosis...
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Screening
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Is acidity the weakness of cancer cells?
Cancer cells proliferating in alkalinity should be more vulnerable in acidic environments, so decreasing the pH may result in decreased proliferation...
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Monoclonal antibodies produced by new cell lines hope to improve drugs
Many biopharmaceutical companies look to produce biosimilars soon, since the patents on the original mAb expire over the next few years...
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The evolving role of three dimensional in-vitro cell culture techniques in drug discovery
Drug discovery is a lengthy process that proceeds through several stages. High throughput screening (HTS) utilising whole-cell based screening assays play a fundamental role as a starting point for identifying novel compounds in the drug discovery process.1,2
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Application note: Cellular and biochemical HTRF assays measured in 1536-well microplates
The PHERAstar FSX microplate reader has been developed to meet the requirements for advanced high throughput screening. The new laser for Time-Resolved-Fluorescence (TRF) assays enables fastest read times for measurement in 1536-well microplates while keeping an excellent assay performance...
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Blood test predicts the best treatment for prostrate cancer
The study showed that patients testing positive for AR-V7 responded better to taxane-based chemotherapy and negative to hormone-targeted therapy...
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Study suggests viral connection to Alzheimer’s disease
A first-of-its-kind study implicates another culprit in the path to Alzheimer's disease: the presence of viruses in the brain...
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Statistical foundation for Next Generation Sequencing built
A statistical foundation for Next Generation Sequencing has been built from samples of 1,036 patients...
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Recessive disorder impairing eyesight has been discovered
Blindness in children has been linked to a recessive genetic disorder caused by the MARK3 gene...
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32,000 images of analysed CT scans released for AI development
Thousands of images have been released to encourage scientists to develop their analysis of lesions, advocating its use for the development of a new universal lesion detector...
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Improving the translation of disease biology though phenomics
How times change. Up to 15 years ago, you would be hard-pressed to find a drug discovery conference with a track dedicated to phenotypic approaches. The underpinning science was called high-content imaging or analysis, being mainly confined to academic drug discovery labs and a handful of pioneers in industry. but…
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Cancer drug screening: the historical perspective
Chemotherapy with cytotoxic and growth inhibitory drugs have played an important role in cancer therapy, used either alone or in combination with other treatment modalities such as surgery, radiation or biological therapy. Chemotherapy, in most instances, was the only alternative treatment for metastatic cancer – mainly given as drug combinations...
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Breath tests could detect pancreatic cancer
Breath tests analysing organic compounds in exhaled breath could be used as a new diagnostic tool for pancreatic cancer...
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Application Note: ATPlite assay performance in human primary cells
ATPliteTM and ATPlite 1step are robust, rapid, high-throughput luminescence assays used to assess a compound’s druggability.
