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Protein phosphorylation inhibition promotes optic nerve regeneration

23 May 2019 | By Drug Target Review

New findings could be translated into the development of novel treatments for patients with optic neuropathies.

news

In-depth research maps virulence factor of the influenza A virus in real time

21 May 2019 | By Drug Target Review

Findings from a recent study could lead to the development of therapeutic approaches against influenza A viruses.

news

Novel findings could improve vaccinations against STIs

20 May 2019 | By Drug Target Review

Researchers have shown how skin vaccinations could be used as a vaccination strategy for sexually transmitted infections (STIs).

news

Researchers take a leap forward for new anti-inflammatory drugs

13 May 2019 | By Drug Target Review

Treatments for chronic inflammatory diseases are one step closer as a new study discovers a way to stop inflammation in its tracks.

news

New study finally explains the link between inflammation and gastric cancer

17 April 2019 | By Drug Target Review

Researchers have finally shown how inflammation caused by H. pylori infection causes the proliferation of gastric epithelial stem cells, leading to gastric tumours.

article

Transforming drug discovery, development and delivery with flow chemistry

11 April 2019 | By Dr Omar Jina - Syrris Ltd, Prof Nicola Tirelli - Italian Institute of Technology Central Research Lab Genova

Flow chemistry is on the rise thanks to the commercial availability of benchtop continuous flow systems that has driven widespread adoption of the technique across a broad range of applications in both academia and industry. In particular, flow chemistry is delivering significant benefits in the area of drug discovery and…

article

Kick-starting the immune response – the shifting landscape of immuno-oncology

29 March 2019 | By Cisbio Bioassays, Nathan Robertson

The landscape of cancer treatment has changed dramatically in the last seven years, beginning with the approval of Ipilmumab in 2011, the first immunotherapy drug. Efforts to unsheathe the tumour cells of their protective microenvironment and expose them to an active immune response have delivered several monoclonal antibodies (mAbs) that…

article

The importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays

21 March 2019 | By Massimiliano Runfola - University of Pisa - Italy, Sheraz Gul - Fraunhofer IME - Germany

Over the past 30 years, one strategy the pharmaceutical industry has adopted in the drug discovery process has been to “fail early, fail often”.1,2 As most molecules in the early stages of drug discovery will have sub-optimal characteristics, significant modification is necessary to improve their properties.

product

Fast molecular interaction screening for all your projects

21 March 2019 | By NanoTemper Technologies

Current technologies that measure molecular interactions for drug discovery slow down and complicate screening. Dianthus is the answer to the demands for fast, non-stop, highly sensitive hit identification, hit validation and lead optimisation.

article

Cell line development – global market drivers, trends and its impact on improving biologics development from early phase to IND during the drug discovery process

19 March 2019 | By Aparajita Dubey - Associate Consultant at Prescient Healthcare Group

Cell line development is a major step for examining the efficiency of drug discovery, toxicity and in vitro testing. It reduces time, effort and cost, which minimises the chance of research drugs failing at the clinical trial stage. This stage involves the production of recombinant proteins such as monoclonal antibodies,…

news

Ticagrelor reversal agent provides immediate and sustained relief

18 March 2019 | By Drug Target Review

A reversal agent that sustains immediate relief from the side effects of ticagrelor stopping major bleeding, such as gastrointestinal hemorrhage...

Drug Target Review issue 1 2019 magazine

article

Drug Target Review – Issue 1 2019

14 March 2019 | By Drug Target Review

In this issue: AI-driven automated chemistry as a tool to accelerate drug discovery processes, the shifting landscape of immuno-oncology, and how lipid molecules provide an insight into biological research.

news

Potential EBV-associated cancer treatment in small molecule inhibitors

7 March 2019 | By Iqra Farooq (Drug Target Review)

A small molecule inhibitor has been observed to activate a dramatic reduction in tumour growth in EBV-associated tumours...

news

Custom-made proteins create antibodies to fight HIV

27 February 2019 | By Drug Target Review

Computational modelling has been used to design proteins that mimic the conserved protein surface of different strains of HIV for use in vaccines...

news

Light-based production of drug discovery molecules

20 February 2019 | By Drug Target Review

Researchers have developed a method of using photocathodes and photoanodes to catalyse reactions that turn organic molecules into drug discovery ones...

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